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Rnf216 ring finger protein 216 [ Mus musculus (house mouse) ]

Gene ID: 108086, updated on 12-May-2024

Summary

Official Symbol
Rnf216provided by MGI
Official Full Name
ring finger protein 216provided by MGI
Primary source
MGI:MGI:1344349
See related
Ensembl:ENSMUSG00000045078 AllianceGenome:MGI:1344349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UIP83; TRIAD3; Ubce7ip1; 2810055G22Rik; F830018F18Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein K48-linked ubiquitination; protein catabolic process; and regulation of defense response to virus by host. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol; nucleoplasm; and synapse. Human ortholog(s) of this gene implicated in Gordon Holmes syndrome. Orthologous to human RNF216 (ring finger protein 216). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 22.7), adrenal adult (RPKM 18.3) and 28 other tissues See more
Orthologs
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Genomic context

See Rnf216 in Genome Data Viewer
Location:
5 G2; 5 81.86 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142976648..143098793, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142990893..143113041, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6395 Neighboring gene STARR-positive B cell enhancer ABC_E674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143670916-143671255 Neighboring gene predicted gene, 38733 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143682513-143682666 Neighboring gene actin, beta Neighboring gene STARR-seq mESC enhancer starr_14775 Neighboring gene STARR-seq mESC enhancer starr_14777 Neighboring gene fascin actin-bundling protein 1 Neighboring gene STARR-seq mESC enhancer starr_14779 Neighboring gene VISTA enhancer mm1619 Neighboring gene predicted gene 43380 Neighboring gene STARR-seq mESC enhancer starr_14782 Neighboring gene STARR-seq mESC enhancer starr_14783 Neighboring gene STARR-positive B cell enhancer ABC_E3631 Neighboring gene STARR-seq mESC enhancer starr_14784 Neighboring gene nonconserved acetylation island sequence M61 enhancer Neighboring gene olfactory receptor family 10 subfamily AH member 1, pseudogene 1 Neighboring gene predicted gene, 38734 Neighboring gene STARR-seq mESC enhancer starr_14788 Neighboring gene predicted gene 7291

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic endocytic zone ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF216
Names
E3 ubiquitin ligase
RING-type E3 ubiquitin transferase RNF216
triad domain-containing protein 3
ubcM4-interacting protein 83
ubiquitin-conjugating enzyme 7-interacting protein 1
NP_001346780.1
NP_542128.2
NP_996993.1
XP_006504707.1
XP_006504708.1
XP_006504709.1
XP_017176080.1
XP_017176081.1
XP_017176082.1
XP_030109902.1
XP_036020615.1
XP_036020616.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359851.1NP_001346780.1  E3 ubiquitin-protein ligase RNF216 isoform C

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) differs in the 5' UTR and coding sequence compared to variant B. The resulting isoform (C) is shorter at the N-terminus compared to isoform B.
    Source sequence(s)
    AC113281
    Conserved Domains (1) summary
    cd16630
    Location:310366
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
  2. NM_080561.4NP_542128.2  E3 ubiquitin-protein ligase RNF216 isoform A

    See identical proteins and their annotated locations for NP_542128.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) uses an alternate in-frame splice junction compared to variant B. The resulting isoform (A) has the same N- and C-termini but is shorter compared to isoform B.
    Source sequence(s)
    BB854046, BC065066
    Consensus CDS
    CCDS80455.1
    UniProtKB/Swiss-Prot
    P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3
    Related
    ENSMUSP00000052563.10, ENSMUST00000053498.13
    Conserved Domains (2) summary
    cd16630
    Location:501557
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    pfam01485
    Location:643693
    IBR; IBR domain, a half RING-finger domain
  3. NM_207110.1NP_996993.1  E3 ubiquitin-protein ligase RNF216 isoform B

    See identical proteins and their annotated locations for NP_996993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) represents the longest transcript and encodes the longest isoform (B).
    Source sequence(s)
    AC113281, AK147861, BB854046, BC065066
    Consensus CDS
    CCDS57400.1
    UniProtKB/Swiss-Prot
    P58283
    Related
    ENSMUSP00000143705.2, ENSMUST00000200607.5
    Conserved Domains (2) summary
    cd16630
    Location:558614
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    pfam01485
    Location:700750
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    142976648..143098793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254042.1XP_030109902.1  E3 ubiquitin-protein ligase RNF216 isoform X4

    Conserved Domains (2) summary
    cd16630
    Location:416472
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    pfam01485
    Location:558608
    IBR; IBR domain, a half RING-finger domain
  2. XM_006504646.4XP_006504709.1  E3 ubiquitin-protein ligase RNF216 isoform X3

    Conserved Domains (2) summary
    cd16630
    Location:473529
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    pfam01485
    Location:615665
    IBR; IBR domain, a half RING-finger domain
  3. XM_006504644.5XP_006504707.1  E3 ubiquitin-protein ligase RNF216 isoform X1

    See identical proteins and their annotated locations for XP_006504707.1

    UniProtKB/Swiss-Prot
    P58283
    Conserved Domains (2) summary
    cd16630
    Location:558614
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    pfam01485
    Location:700750
    IBR; IBR domain, a half RING-finger domain
  4. XM_006504645.5XP_006504708.1  E3 ubiquitin-protein ligase RNF216 isoform X2

    See identical proteins and their annotated locations for XP_006504708.1

    UniProtKB/Swiss-Prot
    P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3
    Conserved Domains (2) summary
    cd16630
    Location:501557
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    pfam01485
    Location:643693
    IBR; IBR domain, a half RING-finger domain
  5. XM_017320593.3XP_017176082.1  E3 ubiquitin-protein ligase RNF216 isoform X5

    Conserved Domains (1) summary
    cd16630
    Location:310366
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
  6. XM_017320592.3XP_017176081.1  E3 ubiquitin-protein ligase RNF216 isoform X5

    Conserved Domains (1) summary
    cd16630
    Location:310366
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
  7. XM_036164722.1XP_036020615.1  E3 ubiquitin-protein ligase RNF216 isoform X1

    Conserved Domains (2) summary
    cd16630
    Location:558614
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    pfam01485
    Location:700750
    IBR; IBR domain, a half RING-finger domain
  8. XM_017320591.3XP_017176080.1  E3 ubiquitin-protein ligase RNF216 isoform X1

    UniProtKB/Swiss-Prot
    P58283
    Conserved Domains (2) summary
    cd16630
    Location:558614
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    pfam01485
    Location:700750
    IBR; IBR domain, a half RING-finger domain
  9. XM_036164723.1XP_036020616.1  E3 ubiquitin-protein ligase RNF216 isoform X2

    UniProtKB/Swiss-Prot
    P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3
    Conserved Domains (2) summary
    cd16630
    Location:501557
    RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    pfam01485
    Location:643693
    IBR; IBR domain, a half RING-finger domain