Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pip4k2bprovided by MGI
Official Full Name: phosphatidylinositol-5-phosphate 4-kinase, type II, betaprovided by MGI
Primary source: MGI:MGI:1934234
See related: Ensembl:ENSMUSG00000018547 AllianceGenome:MGI:1934234
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: c11; Pip5k2b; PI5P4Kbeta
Summary: Predicted to enable phosphatidylinositol kinase activity; protein homodimerization activity; and purine ribonucleoside triphosphate binding activity. Involved in autophagosome-lysosome fusion and regulation of autophagy. Acts upstream of or within phosphatidylinositol metabolic process. Predicted to be located in autophagosome and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in head bone; nervous system; and sensory organ. Orthologous to human PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in CNS E18 (RPKM 28.7), whole brain E14.5 (RPKM 24.4) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 11 D; 11 61.07 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (97605983..97635530, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (97715157..97744704, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.
Title: Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.
Suppression of PIP4K expression selectively prevents tumor cell growth in vitro and prevents tumor development in mice that have lost the tumor suppressor p53. (Review)
Title: PIP4K and the role of nuclear phosphoinositides in tumour suppression.
located within a 185-kb contig surrounding a transgene on chromosome 11
Title: Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130529 (e-PCR)
- UniSTS:213813

AI848124 (e-PCR)
- UniSTS:180304

D11Mit145 (e-PCR), detects polymorphism
- UniSTS:126338

NoName (e-PCR)
- UniSTS:236724

RH125190 (e-PCR)
- UniSTS:162012

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagosome-lysosome fusion	IEA Inferred from Electronic Annotation more info
involved_in autophagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphatidylinositol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol 5-phosphate 4-kinase type-2 beta

Names: 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; diphosphoinositide kinase 2-beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta

NP_473392.1

EC 2.7.1.149

XP_030101326.1

EC 2.7.1.149

XP_036012113.1

EC 2.7.1.149

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054051.1 → NP_473392.1 phosphatidylinositol 5-phosphate 4-kinase type-2 beta

See identical proteins and their annotated locations for NP_473392.1

Status: PROVISIONAL

Source sequence(s)

BC047282

Consensus CDS

CCDS25329.1

UniProtKB/Swiss-Prot

Q80XI4, Q8VHB2

UniProtKB/TrEMBL

Q3UJ95

Related

ENSMUSP00000018691.9, ENSMUST00000018691.10

Conserved Domains (1) summary

cd17310
Location:30 → 413

PIPKc_PIP5K2B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP5K2B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

97605983..97635530 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156220.1 → XP_036012113.1 phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1

Conserved Domains (1) summary

cl28923
Location:1 → 349

PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
XM_030245466.2 → XP_030101326.1 phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1

Conserved Domains (1) summary

cl28923
Location:1 → 349

PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family