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PIP4K2B phosphatidylinositol-5-phosphate 4-kinase type 2 beta [ Homo sapiens (human) ]

Gene ID: 8396, updated on 7-Jun-2020

Summary

Official Symbol
PIP4K2Bprovided by HGNC
Official Full Name
phosphatidylinositol-5-phosphate 4-kinase type 2 betaprovided by HGNC
Primary source
HGNC:HGNC:8998
See related
Ensembl:ENSG00000276293 MIM:603261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI5P4KB; PIP5K2B; PIP5KIIB; PIP5P4KB; PIP5KIIbeta
Summary
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 40.4), ovary (RPKM 23.8) and 24 other tissues See more
Orthologs

Genomic context

See PIP4K2B in Genome Data Viewer
Location:
17q12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (38765691..38799905, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36921944..36956218, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA-Asn (anticodon GTT) 2-5 Neighboring gene RNA, U6 small nuclear 866, pseudogene Neighboring gene proteasome 20S subunit beta 3 Neighboring gene CWC25 spliceosome associated protein homolog Neighboring gene microRNA 4727

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
1-phosphatidylinositol-5-phosphate 4-kinase activity IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
positive regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
autophagosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Names
1-phosphatidylinositol 5-phosphate 4-kinase 2-beta
1-phosphatidylinositol-4-phosphate kinase
PI(5)P 4-kinase type II beta
PIP4KII-beta
PTDINS(4)P-5-kinase
diphosphoinositide kinase 2-beta
phosphatidylinositol 5-phosphate 4-kinase type II beta
phosphatidylinositol-4-phosphate 5-kinase, type II, beta
ptdIns(5)P-4-kinase isoform 2-beta
NP_003550.1
XP_011523628.1
XP_011523629.1
XP_011523632.1
XP_016880686.1
XP_016880688.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003559.4NP_003550.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta

    See identical proteins and their annotated locations for NP_003550.1

    Status: REVIEWED

    Source sequence(s)
    AC006449, AI333549, U85245
    Consensus CDS
    CCDS11329.1
    UniProtKB/Swiss-Prot
    P78356
    Related
    ENSP00000482548.1, ENST00000619039.4
    Conserved Domains (1) summary
    cd00139
    Location:39416
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    38765691..38799905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525326.3XP_011523628.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1

    See identical proteins and their annotated locations for XP_011523628.1

    Conserved Domains (1) summary
    cd00139
    Location:39443
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
  2. XM_011525327.2XP_011523629.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X2

    See identical proteins and their annotated locations for XP_011523629.1

    Conserved Domains (1) summary
    cl02572
    Location:1379
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
  3. XM_017025199.1XP_016880688.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X5

  4. XM_011525330.2XP_011523632.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X3

    See identical proteins and their annotated locations for XP_011523632.1

    Conserved Domains (1) summary
    cl02572
    Location:39283
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
  5. XM_017025197.1XP_016880686.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X4

    Conserved Domains (1) summary
    cl02572
    Location:30277
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    2801010..2835224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138687.1: Suppressed sequence

    Description
    NM_138687.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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