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Skic2 SKI2 subunit of superkiller complex [ Mus musculus (house mouse) ]

Gene ID: 108077, updated on 12-May-2024

Summary

Official Symbol
Skic2provided by MGI
Official Full Name
SKI2 subunit of superkiller complexprovided by MGI
Primary source
MGI:MGI:1099835
See related
Ensembl:ENSMUSG00000040356 AllianceGenome:MGI:1099835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SKI; Ski2; Ddx13; Ski2w; Skiv2l; 4930534J06Rik
Summary
Predicted to enable RNA helicase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay. Predicted to be part of Ski complex. Is expressed in embryo. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 2. Orthologous to human SKIV2L (Ski2 like RNA helicase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 57.5), testis adult (RPKM 55.0) and 28 other tissues See more
Orthologs
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Genomic context

See Skic2 in Genome Data Viewer
Location:
17 B1; 17 18.39 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35058202..35069180, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34839226..34850204, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene C4a promoter region Neighboring gene C4a androgen-responsive enhancer Neighboring gene serine/threonine kinase 19 Neighboring gene STARR-positive B cell enhancer ABC_E8920 Neighboring gene decapping exoribonuclease Neighboring gene microRNA 6971 Neighboring gene microRNA 6970 Neighboring gene STARR-positive B cell enhancer ABC_E5597 Neighboring gene negative elongation factor complex member E, Rdbp Neighboring gene microRNA 6972 Neighboring gene complement factor B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Ski complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ski complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
superkiller complex protein 2
Names
SKI2 subunit of superkiller complex protein
superkiller viralicidic activity 2-like
NP_067312.2
XP_036016152.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021337.2NP_067312.2  superkiller complex protein 2

    See identical proteins and their annotated locations for NP_067312.2

    Status: VALIDATED

    Source sequence(s)
    AK087810, AK159854, CF546171
    Consensus CDS
    CCDS28661.1
    UniProtKB/Swiss-Prot
    Q3TW36, Q6NZR5
    UniProtKB/TrEMBL
    Q8CDP6
    Related
    ENSMUSP00000036265.10, ENSMUST00000046022.16
    Conserved Domains (5) summary
    smart00490
    Location:621705
    HELICc; helicase superfamily c-terminal domain
    COG4581
    Location:2881242
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    pfam00270
    Location:312459
    DEAD; DEAD/DEAH box helicase
    pfam08148
    Location:10701236
    DSHCT; DSHCT (NUC185) domain
    pfam13234
    Location:7621040
    rRNA_proc-arch; rRNA-processing arch domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35058202..35069180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160259.1XP_036016152.1  superkiller complex protein 2 isoform X1

    UniProtKB/TrEMBL
    Q8R3X0
    Conserved Domains (1) summary
    COG4581
    Location:1893
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178062.2: Suppressed sequence

    Description
    NM_178062.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.