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Skic2 SKI2 subunit of superkiller complex [ Mus musculus (house mouse) ]

Gene ID: 108077, updated on 2-Nov-2024

Summary

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Official Symbol
Skic2provided by MGI
Official Full Name
SKI2 subunit of superkiller complexprovided by MGI
Primary source
MGI:MGI:1099835
See related
Ensembl:ENSMUSG00000040356 AllianceGenome:MGI:1099835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SKI; Ski2; Ddx13; Ski2w; Skiv2l; 4930534J06Rik
Summary
Predicted to enable 3'-5' RNA helicase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay and rescue of stalled ribosome. Predicted to be located in nucleus. Predicted to be part of Ski complex. Is expressed in embryo. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 2. Orthologous to human SKIC2 (SKI2 subunit of superkiller complex). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 57.5), testis adult (RPKM 55.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Skic2 in Genome Data Viewer
Location:
17 B1; 17 18.39 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35058202..35069180, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34839226..34850204, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene C4a promoter region Neighboring gene C4a androgen-responsive enhancer Neighboring gene serine/threonine kinase 19 Neighboring gene STARR-positive B cell enhancer ABC_E8920 Neighboring gene decapping exoribonuclease Neighboring gene microRNA 6971 Neighboring gene microRNA 6970 Neighboring gene STARR-positive B cell enhancer ABC_E5597 Neighboring gene negative elongation factor complex member E, Rdbp Neighboring gene microRNA 6972 Neighboring gene complement factor B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease. Yang K, et al. J Clin Invest, 2022 Jan 18. PMID 35040435, Free PMC Article
  2. Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43. Gee S, et al. Proc Natl Acad Sci U S A, 1997 Oct 28. PMID 9342318, Free PMC Article
  3. Molecular analysis of the cDNA and genomic DNA encoding mouse RNA helicase A. Lee CG, et al. Genomics, 1998 Feb 1. PMID 9480750
  4. Organizations and gene duplications of the human and mouse MHC complement gene clusters. Yang Z, et al. Exp Clin Immunogenet, 2000. PMID 10686478
  5. The mouse as a model for the effects of MHC genes on human disease. Allcock RJ, et al. Immunol Today, 2000 Jul. PMID 10871872

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3'-5' RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Ski complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ski complex ISO
Inferred from Sequence Orthology
more info
  
part_of Ski complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
superkiller complex protein 2
Names
SKI2 subunit of superkiller complex protein
superkiller viralicidic activity 2-like
NP_067312.2
XP_036016152.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021337.2 → NP_067312.2  superkiller complex protein 2

    See identical proteins and their annotated locations for NP_067312.2

    Status: VALIDATED

    Source sequence(s)
    AK087810, AK159854, CF546171
    Consensus CDS
    CCDS28661.1
    UniProtKB/Swiss-Prot
    Q3TW36, Q6NZR5
    UniProtKB/TrEMBL
    Q8CDP6
    Related
    ENSMUSP00000036265.10, ENSMUST00000046022.16
    Conserved Domains (5) summary
    smart00490
    Location:621 → 705
    HELICc; helicase superfamily c-terminal domain
    COG4581
    Location:288 → 1242
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    pfam00270
    Location:312 → 459
    DEAD; DEAD/DEAH box helicase
    pfam08148
    Location:1070 → 1236
    DSHCT; DSHCT (NUC185) domain
    pfam13234
    Location:762 → 1040
    rRNA_proc-arch; rRNA-processing arch domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35058202..35069180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160259.1 → XP_036016152.1  superkiller complex protein 2 isoform X1

    UniProtKB/TrEMBL
    Q8R3X0
    Conserved Domains (1) summary
    COG4581
    Location:1 → 893
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178062.2: Suppressed sequence

    Description
    NM_178062.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZR5.1 GenPept UniProtKB/Swiss-Prot:Q6NZR5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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