U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Drgx dorsal root ganglia homeobox [ Mus musculus (house mouse) ]

Gene ID: 107751, updated on 9-May-2024

Summary

Official Symbol
Drgxprovided by MGI
Official Full Name
dorsal root ganglia homeoboxprovided by MGI
Primary source
MGI:MGI:2148204
See related
Ensembl:ENSMUSG00000041730 AllianceGenome:MGI:2148204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drg11; Prrxl1
Summary
Enables DNA binding activity. Acts upstream of or within several processes, including detection of temperature stimulus; nervous system development; and sensory perception of mechanical stimulus. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; and trunk somite. Orthologous to human DRGX (dorsal root ganglia homeobox). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Drgx in Genome Data Viewer
Location:
14 B; 14 19.4 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (32317824..32371203)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32595867..32649246)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene choline O-acetyltransferase Neighboring gene solute carrier family 18 (vesicular monoamine), member 3 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 6 Neighboring gene RIKEN cDNA 3425401B19 gene Neighboring gene STARR-seq mESC enhancer starr_36346 Neighboring gene predicted gene 28651 Neighboring gene predicted gene, 53842

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dorsal root ganglia homeobox protein
Names
dorsal root ganglion 11
homeobox protein DRG11
paired homeodomain protein DRG11
paired related homeobox protein-like 1
paired related homeobox protein-like 1b

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001796.4NP_001001796.1  dorsal root ganglia homeobox protein isoform 2

    See identical proteins and their annotated locations for NP_001001796.1

    Status: VALIDATED

    Source sequence(s)
    CT009541
    Consensus CDS
    CCDS26922.1
    UniProtKB/Swiss-Prot
    Q8BYH0
    Related
    ENSMUSP00000064107.6, ENSMUST00000068938.7
    Conserved Domains (1) summary
    pfam00046
    Location:3789
    Homeobox; Homeobox domain
  2. NM_001347590.1NP_001334519.1  dorsal root ganglia homeobox protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    BQ748034, CJ064638, CT009541
    Consensus CDS
    CCDS84110.1
    UniProtKB/Swiss-Prot
    A2RTS1, B2ZIF3, B2ZIF4, Q8BYH0, Q8K3F8
    Related
    ENSMUSP00000140337.2, ENSMUST00000189022.8
    Conserved Domains (2) summary
    pfam00046
    Location:3790
    Homeobox; Homeobox domain
    pfam03826
    Location:201218
    OAR; OAR domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    32317824..32371203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518412.4XP_006518475.1  dorsal root ganglia homeobox protein isoform X2

    See identical proteins and their annotated locations for XP_006518475.1

    UniProtKB/Swiss-Prot
    A2RTS1, B2ZIF3, B2ZIF4, Q8BYH0, Q8K3F8
    Conserved Domains (2) summary
    pfam00046
    Location:3790
    Homeobox; Homeobox domain
    pfam03826
    Location:201218
    OAR; OAR domain
  2. XM_006518413.4XP_006518476.1  dorsal root ganglia homeobox protein isoform X2

    See identical proteins and their annotated locations for XP_006518476.1

    UniProtKB/Swiss-Prot
    A2RTS1, B2ZIF3, B2ZIF4, Q8BYH0, Q8K3F8
    Conserved Domains (2) summary
    pfam00046
    Location:3790
    Homeobox; Homeobox domain
    pfam03826
    Location:201218
    OAR; OAR domain
  3. XM_006518409.5XP_006518472.1  dorsal root ganglia homeobox protein isoform X1

    Conserved Domains (2) summary
    pfam00046
    Location:128181
    Homeobox; Homeobox domain
    pfam03826
    Location:292309
    OAR; OAR domain
  4. XM_006518414.3XP_006518477.1  dorsal root ganglia homeobox protein isoform X2

    See identical proteins and their annotated locations for XP_006518477.1

    UniProtKB/Swiss-Prot
    A2RTS1, B2ZIF3, B2ZIF4, Q8BYH0, Q8K3F8
    Conserved Domains (2) summary
    pfam00046
    Location:3790
    Homeobox; Homeobox domain
    pfam03826
    Location:201218
    OAR; OAR domain
  5. XM_006518411.3XP_006518474.1  dorsal root ganglia homeobox protein isoform X2

    See identical proteins and their annotated locations for XP_006518474.1

    UniProtKB/Swiss-Prot
    A2RTS1, B2ZIF3, B2ZIF4, Q8BYH0, Q8K3F8
    Related
    ENSMUSP00000139756.2, ENSMUST00000186452.7
    Conserved Domains (2) summary
    pfam00046
    Location:3790
    Homeobox; Homeobox domain
    pfam03826
    Location:201218
    OAR; OAR domain
  6. XM_006518416.4XP_006518479.1  dorsal root ganglia homeobox protein isoform X3

    Conserved Domains (1) summary
    pfam03826
    Location:96113
    OAR; OAR domain