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DRGX dorsal root ganglia homeobox [ Homo sapiens (human) ]

Gene ID: 644168, updated on 23-Nov-2021

Summary

Official Symbol
DRGXprovided by HGNC
Official Full Name
dorsal root ganglia homeoboxprovided by HGNC
Primary source
HGNC:HGNC:21536
See related
Ensembl:ENSG00000165606 MIM:606701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRG11; PRRXL1
Expression
Biased expression in adrenal (RPKM 3.2) and skin (RPKM 0.2) See more
Orthologs
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Genomic context

See DRGX in Genome Data Viewer
Location:
10q11.23
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (49364066..49396089, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50572111..50604135, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 273 Neighboring gene C10orf71 antisense RNA 1 Neighboring gene chromosome 10 open reading frame 71 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 17 Neighboring gene ERCC excision repair 6, chromatin remodeling factor Neighboring gene piggyBac transposable element derived 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
GeneReviews: Not available

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of temperature stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in dorsal spinal cord development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sensory perception of mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in trigeminal nerve development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dorsal root ganglia homeobox protein
Names
paired related homeobox-like 1
paired-like homeodomain trancription factor DRG11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276451.2NP_001263380.1  dorsal root ganglia homeobox protein

    See identical proteins and their annotated locations for NP_001263380.1

    Status: VALIDATED

    Source sequence(s)
    AC027674
    Consensus CDS
    CCDS44388.2
    UniProtKB/Swiss-Prot
    A6NNA5
    Related
    ENSP00000363254.1, ENST00000374139.8
    Conserved Domains (2) summary
    pfam00046
    Location:3789
    Homeobox; Homeobox domain
    pfam03826
    Location:201217
    OAR; OAR domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    49364066..49396089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540089.3XP_011538391.1  dorsal root ganglia homeobox protein isoform X1

    Conserved Domains (2) summary
    pfam00046
    Location:37124
    Homeobox; Homeobox domain
    pfam03826
    Location:236252
    OAR; OAR domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080520.1: Suppressed sequence

    Description
    NM_001080520.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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