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DRGX dorsal root ganglia homeobox [ Homo sapiens (human) ]

Gene ID: 644168, updated on 25-Nov-2025
Official Symbol
DRGXprovided by HGNC
Official Full Name
dorsal root ganglia homeoboxprovided by HGNC
Primary source
HGNC:HGNC:21536
See related
Ensembl:ENSG00000165606 MIM:606701; AllianceGenome:HGNC:21536
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRG11; PRRXL1
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including detection of temperature stimulus; nervous system development; and sensory perception of mechanical stimulus. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in adrenal (RPKM 3.2) and skin (RPKM 0.2) See more
Orthologs
mouse all
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See DRGX in Genome Data Viewer
Location:
10q11.23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (49364066..49396089, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (50212849..50244874, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50572111..50604135, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50378847-50379346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50382921-50383422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50383423-50383922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3347 Neighboring gene transmembrane protein 273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3349 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:50451046-50451717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50462512-50463040 Neighboring gene C10orf71 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:50505091-50505268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2361 Neighboring gene chromosome 10 open reading frame 71 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:50543527-50544726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50587592-50588092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2362 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 17 Neighboring gene ERCC excision repair 6, chromatin remodeling factor Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:50679962-50681161 Neighboring gene piggyBac transposable element derived 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Genome-wide association analysis of Sasang constitution in the Korean population. Kim BY, et al. J Altern Complement Med, 2012 Mar. PMID 22394158, Free PMC Article
  2. Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets. Saito T, et al. Mol Cell Neurosci, 1995 Jun. PMID 7496632
  3. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. Aslibekyan S, et al. Pharmacogenet Genomics, 2012 Mar. PMID 22228203, Free PMC Article
  4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  5. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within axonogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within detection of chemical stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within detection of temperature stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dorsal spinal cord development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sensory perception of mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within trigeminal nerve development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
dorsal root ganglia homeobox protein
Names
paired related homeobox-like 1
paired-like homeodomain trancription factor DRG11

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276451.2 → NP_001263380.1  dorsal root ganglia homeobox protein

    See identical proteins and their annotated locations for NP_001263380.1

    Status: VALIDATED

    Source sequence(s)
    AC027674
    Consensus CDS
    CCDS44388.2
    UniProtKB/Swiss-Prot
    A6NNA5
    Related
    ENSP00000363254.1, ENST00000374139.8
    Conserved Domains (2) summary
    pfam00046
    Location:37 → 89
    Homeobox; Homeobox domain
    pfam03826
    Location:201 → 217
    OAR; OAR domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    49364066..49396089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540089.4 → XP_011538391.1  dorsal root ganglia homeobox protein isoform X1

    Conserved Domains (2) summary
    pfam00046
    Location:37 → 124
    Homeobox; Homeobox domain
    pfam03826
    Location:236 → 252
    OAR; OAR domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    50212849..50244874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366590.1 → XP_054222565.1  dorsal root ganglia homeobox protein isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080520.1: Suppressed sequence

    Description
    NM_001080520.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NNA5.1 GenPept UniProtKB/Swiss-Prot:A6NNA5

Gene LinkOut

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