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PLK2 polo like kinase 2 [ Homo sapiens (human) ]

Gene ID: 10769, updated on 7-Jul-2019

Summary

Official Symbol
PLK2provided by HGNC
Official Full Name
polo like kinase 2provided by HGNC
Primary source
HGNC:HGNC:19699
See related
Ensembl:ENSG00000145632 MIM:607023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNK; hSNK; hPlk2
Summary
The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Broad expression in spleen (RPKM 41.3), placenta (RPKM 28.6) and 25 other tissues See more
Orthologs

Genomic context

See PLK2 in Genome Data Viewer
Location:
5q11.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (58453982..58460139, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (57749809..57755966, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378983 Neighboring gene uncharacterized LOC105378984 Neighboring gene GRB2 binding adaptor protein, transmembrane Neighboring gene microRNA 548ae-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Rap protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term synaptic depression ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
memory ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic spindle organization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process in bone marrow IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of centriole replication IDA
Inferred from Direct Assay
more info
PubMed 
regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase PLK2
Names
PLK-2
serine/threonine-protein kinase SNK
serum-inducible kinase
NP_001239155.1
NP_006613.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252226.1NP_001239155.1  serine/threonine-protein kinase PLK2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced in the 5' region compared to variant 1, however, it maintains the reading frame and encodes a shorter isoform (2) missing a 14 aa protein segment compared to isoform 1.
    Source sequence(s)
    AA954432, AK027851, BC013879, BI559351, N66865
    Consensus CDS
    CCDS75250.1
    UniProtKB/Swiss-Prot
    Q9NYY3
    UniProtKB/TrEMBL
    A0A087WUH9
    Related
    ENSP00000478685.1, ENST00000617412.1
    Conserved Domains (4) summary
    smart00220
    Location:68320
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13117
    Location:587668
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:489574
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14188
    Location:66320
    STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2
  2. NM_006622.4NP_006613.2  serine/threonine-protein kinase PLK2 isoform 1

    See identical proteins and their annotated locations for NP_006613.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AA954432, AK027851, BC013879, N66865
    Consensus CDS
    CCDS3974.1
    UniProtKB/Swiss-Prot
    Q9NYY3
    UniProtKB/TrEMBL
    A0A024QZV1
    Related
    ENSP00000274289.3, ENST00000274289.8
    Conserved Domains (4) summary
    smart00220
    Location:82334
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13117
    Location:601682
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:503588
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14188
    Location:80334
    STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    58453982..58460139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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