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TOB2 transducer of ERBB2, 2 [ Homo sapiens (human) ]

Gene ID: 10766, updated on 10-Oct-2019

Summary

Official Symbol
TOB2provided by HGNC
Official Full Name
transducer of ERBB2, 2provided by HGNC
Primary source
HGNC:HGNC:11980
See related
Ensembl:ENSG00000183864 MIM:607396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOB4; TOBL; APRO5; TROB2
Summary
TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in fat (RPKM 15.5), thyroid (RPKM 14.3) and 25 other tissues See more
Orthologs

Genomic context

See TOB2 in Genome Data Viewer
Location:
22q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (41433492..41448230, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41829492..41844234, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373042 Neighboring gene RNA, U6 small nuclear 495, pseudogene Neighboring gene TEF transcription factor, PAR bZIP family member Neighboring gene HNF4 motif-containing MPRA enhancer 178 Neighboring gene uncharacterized LOC105373043 Neighboring gene PHD finger protein 5A Neighboring gene aconitase 2 Neighboring gene Sharpr-MPRA regulatory region 731

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
NHGRI GWA Catalog

Pathways from BioSystems

  • Bone Morphogenic Protein (BMP) Signalling and Regulation, organism-specific biosystem (from WikiPathways)
    Bone Morphogenic Protein (BMP) Signalling and Regulation, organism-specific biosystem"BMP signals are mediated by type I and II BMP receptors and their downstream molecules Smad1, 5 and 8. Phosphorylated Smad1, 5 and 8 proteins form a complex with Smad4 and then are translocated into...
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vitamin D receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
female gamete generation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein Tob2
Names
protein Tob4
transducer of erbB-2 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016272.4NP_057356.1  protein Tob2

    See identical proteins and their annotated locations for NP_057356.1

    Status: VALIDATED

    Source sequence(s)
    AB051450, AI362988, BC038957, BM453650
    Consensus CDS
    CCDS14015.1
    UniProtKB/Swiss-Prot
    Q14106
    Related
    ENSP00000331305.3, ENST00000327492.4
    Conserved Domains (1) summary
    pfam07742
    Location:1112
    BTG; BTG family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    41433492..41448230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261315.2XP_005261372.1  protein Tob2 isoform X1

    See identical proteins and their annotated locations for XP_005261372.1

    UniProtKB/Swiss-Prot
    Q14106
    Conserved Domains (1) summary
    pfam07742
    Location:1112
    BTG; BTG family
  2. XM_017028539.1XP_016884028.1  protein Tob2 isoform X1

    UniProtKB/Swiss-Prot
    Q14106
    Conserved Domains (1) summary
    pfam07742
    Location:1112
    BTG; BTG family
  3. XM_006724105.3XP_006724168.1  protein Tob2 isoform X1

    See identical proteins and their annotated locations for XP_006724168.1

    UniProtKB/Swiss-Prot
    Q14106
    Conserved Domains (1) summary
    pfam07742
    Location:1112
    BTG; BTG family
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