Tob2 transducer of ERBB2, 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tob2provided by MGI
Official Full Name: transducer of ERBB2, 2provided by MGI
Primary source: MGI:MGI:1888525
See related: Ensembl:ENSMUSG00000048546 AllianceGenome:MGI:1888525
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1663; 2900090N22Rik; 4930545K18Rik
Summary: Enables vitamin D receptor binding activity. Acts upstream of or within negative regulation of osteoclast differentiation; positive regulation of ossification; and regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Meckel's cartilage; genitourinary system; liver; orbito-sphenoid; and spleen. Orthologous to human TOB2 (transducer of ERBB2, 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 33.9), thymus adult (RPKM 22.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15; 15 E1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (81732471..81744742, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (81848270..81858326, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tob2 Inhibits TLR-Induced Inflammatory Responses by Association with TRAF6 and MyD88.
Title: Tob2 Inhibits TLR-Induced Inflammatory Responses by Association with TRAF6 and MyD88.
These results revealed a new molecular mechanism that fine-tunes osteoblast differentiation through miR-5100/Tob2/osterix networks.
Title: MiR-5100 promotes osteogenic differentiation by targeting Tob2.
Tob1(-/-), Tob2(-/-), and Tob1/2 double knockout (DKO, Tob1(-/-) & Tob2(-/-)) embryonic stem cells (ESCs) grew faster than wild type (WT) ESCs without losing pluripotency.
Title: BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation.
miR-322 and its target protein Tob2 modulate Osx mRNA stability
Title: MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability.
Tob2 protein suppresses PPARgamma2 transcription by inhibiting BMP2-induced Smad1/5 phosphorylation through its interaction with Smad6 and by sequestering C/EBPalpha from the PPARgamma2 promoter.
Title: Tob2 inhibits peroxisome proliferator-activated receptor γ2 expression by sequestering Smads and C/EBPα during adipocyte differentiation.
Tob2 negatively regulates formation of osteoclasts by suppressing RANKL expression through its interaction with vitamin D receptor
Title: Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Tob2 gene: The Tob2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 348 organisms have orthologs with human gene Tob2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear vitamin D receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: protein Tob2

Names: transducer of erbB-2 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020507.3 → NP_065253.1 protein Tob2

See identical proteins and their annotated locations for NP_065253.1

Status: VALIDATED

Source sequence(s)

AK049766, AK143542, AV220845, CK618657, DV644744

Consensus CDS

CCDS27673.1

UniProtKB/Swiss-Prot

Q9JM55

UniProtKB/TrEMBL

Q543X9

Related

ENSMUSP00000061390.8, ENSMUST00000050467.9

Conserved Domains (1) summary

cl15439
Location:1 → 106

BTG; BTG family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

81732471..81744742 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159530.1 → XP_036015423.1 protein Tob2 isoform X1

UniProtKB/Swiss-Prot

Q9JM55

UniProtKB/TrEMBL

Q543X9

Conserved Domains (1) summary

cl15439
Location:1 → 106

BTG; BTG family
XM_036159531.1 → XP_036015424.1 protein Tob2 isoform X1

UniProtKB/Swiss-Prot

Q9JM55

UniProtKB/TrEMBL

Q543X9

Conserved Domains (1) summary

cl15439
Location:1 → 106

BTG; BTG family