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PLAC1 placenta enriched 1 [ Homo sapiens (human) ]

Gene ID: 10761, updated on 2-Nov-2024

Summary

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Official Symbol
PLAC1provided by HGNC
Official Full Name
placenta enriched 1provided by HGNC
Primary source
HGNC:HGNC:9044
See related
Ensembl:ENSG00000170965 MIM:300296; AllianceGenome:HGNC:9044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT92; OOSP2B; OOSP2L
Summary
Involved in placenta development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward placenta (RPKM 19.2) See more
Orthologs
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Genomic context

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See PLAC1 in Genome Data Viewer
Location:
Xq26.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (134565838..134764322, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (132891012..133089435, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (133699868..133898352, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:133684089-133684718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:133684719-133685347 Neighboring gene MIR503 host gene Neighboring gene long intergenic non-protein coding RNA 629 Neighboring gene microRNA 424 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:133737986-133739185 Neighboring gene ribosomal protein L21 pseudogene 133 Neighboring gene ribosomal protein S7 pseudogene 12 Neighboring gene RNA, U4 small nuclear 44, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21014 Neighboring gene PABIR family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29977 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:133942169-133943125 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21015 Neighboring gene PABIR family member 3 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:133966100-133966314 Neighboring gene Sharpr-MPRA regulatory region 6850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21016 Neighboring gene motile sperm domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Expression of PLAC1/CP1 genes in primary colorectal carcinoma and its clinical significance]. Liu FF, et al. Zhonghua Bing Li Xue Za Zhi, 2010 Dec. PMID 21215095
  2. Optimized protocol for soluble prokaryotic expression, purification and structural analysis of human placenta specific-1(PLAC1). Nazari M, et al. Protein Expr Purif, 2017 May. PMID 28315746
  3. Oncogenic function of Plac1 on the proliferation and metastasis in hepatocellular carcinoma cells. Wu Y, et al. Oncol Rep, 2017 Jan. PMID 27878289
  4. PLAC1 is involved in human trophoblast syncytialization. Chang WL, et al. Reprod Biol, 2016 Sep. PMID 27692364
  5. New tumour antigen PLAC1/CP1, a potentially useful prognostic marker and immunotherapy target for gastric adenocarcinoma. Liu F, et al. J Clin Pathol, 2015 Nov. PMID 26157147

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential expression of PLAC1 and Netrin-1 in liver metastasis of colorectal cancer and its predictive value.
    Title: Differential expression of PLAC1 and Netrin-1 in liver metastasis of colorectal cancer and its predictive value.
  2. The Oncogenic Theory of Preeclampsia: Is Amniotic Mesenchymal Stem Cells-Derived PLAC1 Involved?
    Title: The Oncogenic Theory of Preeclampsia: Is Amniotic Mesenchymal Stem Cells-Derived PLAC1 Involved?
  3. Placenta-specific protein 1 (PLAC1) expression is significantly down-regulated in preeclampsia via a hypoxia-mediated mechanism.
    Title: Placenta-specific protein 1 (PLAC1) expression is significantly down-regulated in preeclampsia via a hypoxia-mediated mechanism.
  4. Placenta-specific protein 1 enhances liver metastatic potential and is associated with the PI3K/AKT/NF-kappaB signaling pathway in colorectal cancer.
    Title: Placenta-specific protein 1 enhances liver metastatic potential and is associated with the PI3K/AKT/NF-κB signaling pathway in colorectal cancer.
  5. Placenta-specific protein 1 promotes cell proliferation via the AKT/GSK-3beta/cyclin D1 signaling pathway in gastric cancer.
    Title: Placenta-specific protein 1 promotes cell proliferation via the AKT/GSK-3β/cyclin D1 signaling pathway in gastric cancer.
  6. PLAC1 affects cell to cell communication by interacting with the desmosome complex.
    Title: PLAC1 affects cell to cell communication by interacting with the desmosome complex.
  7. PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer.
    Title: PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer.
  8. Expression level of PLAC1 in osteosarcoma patients and its regulatory effect on the development of osteosarcoma.
    Title: Expression level of PLAC1 in osteosarcoma patients and its regulatory effect on the development of osteosarcoma.
  9. Plac1 promotes nasopharyngeal carcinoma cells proliferation, migration and invasion via Furin/NICD/PTEN pathway.
    Title: Plac1 promotes nasopharyngeal carcinoma cells proliferation, migration and invasion via Furin/NICD/PTEN pathway.
  10. Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma.
    Title: Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in placenta development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
placenta-specific protein 1
Names
cancer/testis antigen 92
placenta specific 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316887.2 → NP_001303816.1  placenta-specific protein 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC004383, AK075086, BG436529
    Consensus CDS
    CCDS14642.1
    UniProtKB/Swiss-Prot
    Q9HBJ0

  2. NM_001316888.2 → NP_001303817.1  placenta-specific protein 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC004383, AK075086, BG436529, N55828
    Consensus CDS
    CCDS14642.1
    UniProtKB/Swiss-Prot
    Q9HBJ0
    Related
    ENST00000476971.5

  3. NM_001316889.2 → NP_001303818.1  placenta-specific protein 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC004383, AK075086, BC066327
    Consensus CDS
    CCDS14642.1
    UniProtKB/Swiss-Prot
    Q9HBJ0

  4. NM_021796.4 → NP_068568.1  placenta-specific protein 1 precursor

    See identical proteins and their annotated locations for NP_068568.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. All four variants encode the same protein.
    Source sequence(s)
    AC004383, AK075086
    Consensus CDS
    CCDS14642.1
    UniProtKB/Swiss-Prot
    Q9HBJ0
    Related
    ENSP00000352173.4, ENST00000359237.9

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    134565838..134764322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441789.1 → XP_047297745.1  placenta-specific protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9HBJ0

  2. XM_011531257.3 → XP_011529559.1  placenta-specific protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011529559.1

    UniProtKB/Swiss-Prot
    Q9HBJ0

  3. XM_011531260.3 → XP_011529562.1  placenta-specific protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011529562.1

    UniProtKB/Swiss-Prot
    Q9HBJ0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    132891012..133089435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326401.1 → XP_054182376.1  placenta-specific protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9HBJ0

  2. XM_054326400.1 → XP_054182375.1  placenta-specific protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9HBJ0

  3. XM_054326399.1 → XP_054182374.1  placenta-specific protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9HBJ0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HBJ0.1 GenPept UniProtKB/Swiss-Prot:Q9HBJ0

Gene LinkOut

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