Plac1 placental specific protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plac1provided by MGI
Official Full Name: placental specific protein 1provided by MGI
Primary source: MGI:MGI:1926287
See related: Ensembl:ENSMUSG00000061082 AllianceGenome:MGI:1926287
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Epcs26; Oosp2l; DXWsu72e
Summary: Involved in placenta development. Acts upstream of or within spongiotrophoblast layer developmental growth. Predicted to be located in extracellular region. Is expressed in several structures, including body wall mesenchyme; brain; extraembryonic component; genitourinary system; and lung. Orthologous to human PLAC1 (placenta enriched 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward placenta adult (RPKM 67.5) See more
Orthologs: all
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Genomic context

Location:: X A5; X 29.31 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (52158870..52328969, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (53069993..53240110, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immunization with placenta-specific 1 (plac1) induces potent anti-tumor responses and prolongs survival in a mouse model of melanoma.
Title: Immunization with placenta-specific 1 (plac1) induces potent anti-tumor responses and prolongs survival in a mouse model of melanoma.
Results provide evidence that Plac1 modulates a tolerogenic tumor microenvironment in part by modulating the chemokine axis in mammary tumors.
Title: Plac1 Is a Key Regulator of the Inflammatory Response and Immune Tolerance In Mammary Tumorigenesis.
Upon meiosis onset, active furin/IGF-1 receptor relocates into the cytoplasm to activate (phosphorylate) Akt to promote meiosis. In summary, our finding suggests that Plac1, a protein that is crucial for placentation, is also essential for oocyte meiosis and fertilization.
Title: Placenta-specific 1 regulates oocyte meiosis and fertilization through furin.
Plac1 is abundantly expressed at the fetomaternal interface and in all trophoblast subtypes except in primary trophoblast giant cells. Plac1 knockdown retarded the progress of TS differentiation, indicating that Plac1 is necessary for normal trophoblast differentiation into various trophoblast subpopulations.
Title: Plac1 Expression Pattern at the Mouse Fetomaternal Interface and Involvement in Trophoblast Differentiation.
Our findings suggest that Plac1 is involved in trophoblast cell proliferation, differentiation, and migration
Title: Lentiviral Vector-Mediated Complementation Restored Fetal Viability but Not Placental Hyperplasia in Plac1-Deficient Mice.
Plac1 (placenta-specific 1) is widely expressed during fetal development and is associated with a lethal form of hydrocephalus.
Title: Plac1 (placenta-specific 1) is widely expressed during fetal development and is associated with a lethal form of hydrocephalus.
Plac1 is a paternally imprinted, X-linked gene essential for normal placental and embryonic development.
Title: Plac1 (placenta-specific 1) is essential for normal placental and embryonic development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

DXJti2 (e-PCR), detects polymorphism
- UniSTS:142894

DXJti3 (e-PCR), detects polymorphism
- UniSTS:142895

DXWsu72e (e-PCR), detects polymorphism
- UniSTS:142928

Plac1 (e-PCR), detects polymorphism
- UniSTS:166283

RH126503 (e-PCR)
- UniSTS:209651

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in placenta development	IEA Inferred from Electronic Annotation more info
involved_in placenta development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spongiotrophoblast layer developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: placenta-specific protein 1

Names: ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.