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Eprs glutamyl-prolyl-tRNA synthetase [ Mus musculus (house mouse) ]

Gene ID: 107508, updated on 8-Jan-2023

Summary

Official Symbol
Eprsprovided by MGI
Official Full Name
glutamyl-prolyl-tRNA synthetaseprovided by MGI
Primary source
MGI:MGI:97838
See related
Ensembl:ENSMUSG00000026615 AllianceGenome:MGI:97838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Qprs; Eprs1; 2410081F06Rik; 3010002K18Rik
Summary
Enables proline-tRNA ligase activity. Involved in several processes, including cellular response to insulin stimulus; prolyl-tRNA aminoacylation; and regulation of long-chain fatty acid import into cell. Acts upstream of or within cellular response to interferon-gamma. Located in plasma membrane. Part of GAIT complex and aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; axial skeleton; craniocervical region bone; face; and liver. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 17.5), liver E14 (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

See Eprs in Genome Data Viewer
Location:
1; 1 H5
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (185093614..185160557)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (185361417..185428360)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene isoleucine-tRNA synthetase 2, mitochondrial Neighboring gene RIKEN cDNA 2010103J01 gene Neighboring gene microRNA 215 Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 1 Neighboring gene RIKEN cDNA 9630028B13 gene Neighboring gene predicted gene 2061 Neighboring gene solute carrier family 30, member 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables glutamate-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables proline-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables proline-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables proline-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in glutamyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in prolyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in prolyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prolyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of long-chain fatty acid import into cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of long-chain fatty acid import into cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bifunctional glutamate/proline--tRNA ligase
Names
bifunctional aminoacyl-tRNA synthetase
glutamine-proline-tRNA synthetase
NP_001344403.1
NP_084011.1
XP_017176142.1
XP_030110720.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357474.1NP_001344403.1  bifunctional glutamate/proline--tRNA ligase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129195, AC131980
    Conserved Domains (3) summary
    PRK08661
    Location:10261519
    PRK08661; prolyl-tRNA synthetase; Provisional
    cd00936
    Location:760809
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
    cl27212
    Location:6718
    GlnS; Glutamyl- or glutaminyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
  2. NM_029735.2NP_084011.1  bifunctional glutamate/proline--tRNA ligase isoform 1

    See identical proteins and their annotated locations for NP_084011.1

    Status: VALIDATED

    Source sequence(s)
    AI845980, AK141072, BC058337, BC094679, CB520692, CF537682, CK635189
    Consensus CDS
    CCDS35818.1
    UniProtKB/Swiss-Prot
    Q4VC16, Q8CGC7
    Related
    ENSMUSP00000045841.8, ENSMUST00000046514.13
    Conserved Domains (8) summary
    cd10309
    Location:74157
    GST_C_GluProRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of bifunctional Glutamyl-Prolyl-tRNA synthetase
    PLN02907
    Location:6711
    PLN02907; glutamate-tRNA ligase
    PRK08661
    Location:10191512
    PRK08661; prolyl-tRNA synthetase; Provisional
    cd00778
    Location:10231286
    ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cd00862
    Location:12921512
    ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
    pfam00458
    Location:753805
    WHEP-TRS; WHEP-TRS domain
    pfam00749
    Location:197502
    tRNA-synt_1c; tRNA synthetases class I (E and Q), catalytic domain
    pfam03950
    Location:504681
    tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    185093614..185160557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320653.2XP_017176142.1  bifunctional glutamate/proline--tRNA ligase isoform X2

    Conserved Domains (4) summary
    PLN02907
    Location:2454
    PLN02907; glutamate-tRNA ligase
    PRK08661
    Location:7621255
    PRK08661; prolyl-tRNA synthetase; Provisional
    cd00936
    Location:496545
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
    pfam00458
    Location:569621
    WHEP-TRS; WHEP-TRS domain
  2. XM_030254860.2XP_030110720.1  bifunctional glutamate/proline--tRNA ligase isoform X1

    Conserved Domains (4) summary
    PLN02907
    Location:2461
    PLN02907; glutamate-tRNA ligase
    PRK08661
    Location:7691262
    PRK08661; prolyl-tRNA synthetase; Provisional
    cd00936
    Location:503552
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
    pfam00458
    Location:576628
    WHEP-TRS; WHEP-TRS domain