Format

Send to:

Choose Destination

GRAP GRB2 related adaptor protein [ Homo sapiens (human) ]

Gene ID: 10750, updated on 27-Jun-2020

Summary

Official Symbol
GRAPprovided by HGNC
Official Full Name
GRB2 related adaptor proteinprovided by HGNC
Primary source
HGNC:HGNC:4562
See related
Ensembl:ENSG00000154016 MIM:604330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DFNB114
Summary
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]
Expression
Broad expression in lymph node (RPKM 19.4), spleen (RPKM 17.2) and 19 other tissues See more
Orthologs

Genomic context

See GRAP in Genome Data Viewer
Location:
17p11.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (19020656..19046957, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18923969..18950336, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene solute carrier family 5 member 10 Neighboring gene family with sequence similarity 83 member G Neighboring gene uncharacterized LOC112268188 Neighboring gene small nucleolar RNA, C/D box 3B-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of GRB2-related adaptor protein (GRAP) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC64880

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
sensory perception of sound IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
presynapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
GRB2-related adapter protein
Names
growth factor receptor-bound protein 2-related adaptor protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330148.2NP_001317077.1  GRB2-related adapter protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AI362516, BC035856, BG684099, BI906472
    Consensus CDS
    CCDS82085.1
    UniProtKB/Swiss-Prot
    Q13588
    UniProtKB/TrEMBL
    I3L2P9
    Related
    ENSP00000459833.1, ENST00000573099.5
    Conserved Domains (2) summary
    cd11948
    Location:255
    SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
    cl15255
    Location:56101
    SH2; Src homology 2 (SH2) domain
  2. NM_006613.4NP_006604.1  GRB2-related adapter protein isoform 1

    See identical proteins and their annotated locations for NP_006604.1

    Status: REVIEWED

    Source sequence(s)
    AC003957, BC063035
    Consensus CDS
    CCDS11202.1
    UniProtKB/Swiss-Prot
    Q13588
    Related
    ENSP00000284154.5, ENST00000284154.9
    Conserved Domains (3) summary
    cd09941
    Location:56150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11948
    Location:255
    SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
    cd11951
    Location:162214
    SH3_GRAP_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    19020656..19046957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center