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RFPL3 ret finger protein like 3 [ Homo sapiens (human) ]

Gene ID: 10738, updated on 23-Nov-2021

Summary

Official Symbol
RFPL3provided by HGNC
Official Full Name
ret finger protein like 3provided by HGNC
Primary source
HGNC:HGNC:9980
See related
Ensembl:ENSG00000128276 MIM:605970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF120
Expression
Biased expression in testis (RPKM 12.5) and prostate (RPKM 0.7) See more
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Genomic context

See RFPL3 in Genome Data Viewer
Location:
22q12.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (32354885..32361161)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (32750872..32757148)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene SLC5A4 antisense RNA 1 Neighboring gene solute carrier family 5 member 4 Neighboring gene CPSF1 pseudogene 1 Neighboring gene uncharacterized LOC107985561 Neighboring gene RFPL3 antisense Neighboring gene immunoglobulin lambda constant/OR22-2 (pseudogene) Neighboring gene ral guanine nucleotide dissociation stimulator like 4 pseudogene Neighboring gene uncharacterized LOC339666

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol RFPL3 enhances the preintegration complex (PIC) integration activity in vitro, suggesting that HIV-1 IN interacts with RFPL3 in cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098535.1NP_001092005.1  ret finger protein-like 3 isoform 1

    See identical proteins and their annotated locations for NP_001092005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL021937, CR456564
    Consensus CDS
    CCDS43011.1
    UniProtKB/Swiss-Prot
    O75679
    Related
    ENSP00000249007.4, ENST00000249007.4
    Conserved Domains (3) summary
    pfam11002
    Location:83124
    RDM; RFPL defining motif (RDM)
    pfam15227
    Location:4081
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15821
    Location:122299
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
  2. NM_006604.2NP_006595.1  ret finger protein-like 3 isoform 2

    See identical proteins and their annotated locations for NP_006595.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL021937, BC031689
    Consensus CDS
    CCDS13904.1
    UniProtKB/Swiss-Prot
    O75679
    Related
    ENSP00000380609.1, ENST00000397468.5
    Conserved Domains (3) summary
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    pfam15227
    Location:1152
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    32354885..32361161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028534.1XP_016884023.1  ret finger protein-like 3 isoform X1

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