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PLK4 polo like kinase 4 [ Homo sapiens (human) ]

Gene ID: 10733, updated on 9-Jul-2019

Summary

Official Symbol
PLK4provided by HGNC
Official Full Name
polo like kinase 4provided by HGNC
Primary source
HGNC:HGNC:11397
See related
Ensembl:ENSG00000142731 MIM:605031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAK; STK18; MCCRP2
Summary
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Biased expression in testis (RPKM 12.2), bone marrow (RPKM 8.2) and 12 other tissues See more
Orthologs

Genomic context

See PLK4 in Genome Data Viewer
Location:
4q28.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (127880893..127899224)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (128802016..128820379)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SOSS complex subunit C pseudogene Neighboring gene heat shock protein family A (Hsp70) member 4 like Neighboring gene ribosomal protein L21 pseudogene 53 Neighboring gene RNA, U6 small nuclear 583, pseudogene Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene abhydrolase domain containing 18 Neighboring gene La ribonucleoprotein domain family member 1B Neighboring gene ribosomal protein L15 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
de novo centriole assembly involved in multi-ciliated epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of centriole replication IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
trophoblast giant cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
XY body IEA
Inferred from Electronic Annotation
more info
 
centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
deuterosome ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PLK4
Names
Snk akin kinase
serine/threonine-protein kinase 18
serine/threonine-protein kinase Sak
NP_001177728.1
NP_001177730.1
NP_055079.3
XP_005262758.1
XP_016863151.1
XP_016863152.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041821.1 RefSeqGene

    Range
    5001..23364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190799.2NP_001177728.1  serine/threonine-protein kinase PLK4 isoform 2

    See identical proteins and their annotated locations for NP_001177728.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' coding exon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI088969, AK303399, BU633758, DC402409
    Consensus CDS
    CCDS54803.1
    UniProtKB/Swiss-Prot
    O00444
    Related
    ENSP00000427554.1, ENST00000513090.5
    Conserved Domains (5) summary
    smart00220
    Location:12233
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:555666
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:667775
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:852931
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cl21453
    Location:10233
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001190801.1NP_001177730.1  serine/threonine-protein kinase PLK4 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different first exon, which results in the use of a in-frame downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI088969, AK302858, BC036023, BU633758
    Consensus CDS
    CCDS54804.1
    UniProtKB/Swiss-Prot
    O00444
    Related
    ENSP00000423582.1, ENST00000514379.5
    Conserved Domains (5) summary
    smart00220
    Location:1224
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:546657
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:658766
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:843922
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cl21453
    Location:1224
    PKc_like; Protein Kinases, catalytic domain
  3. NM_014264.5NP_055079.3  serine/threonine-protein kinase PLK4 isoform 1

    See identical proteins and their annotated locations for NP_055079.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AI088969, BC036023, BU633758
    Consensus CDS
    CCDS3735.1
    UniProtKB/Swiss-Prot
    O00444
    Related
    ENSP00000270861.5, ENST00000270861.10
    Conserved Domains (5) summary
    smart00220
    Location:12265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:587698
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:699807
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:884963
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd14186
    Location:10265
    STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    127880893..127899224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262701.3XP_005262758.1  serine/threonine-protein kinase PLK4 isoform X3

    Related
    ENSP00000423412.1, ENST00000507249.5
    Conserved Domains (5) summary
    smart00220
    Location:12265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:553664
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:665773
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:850929
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd14186
    Location:10265
    STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4
  2. XM_017007663.2XP_016863152.1  serine/threonine-protein kinase PLK4 isoform X2

  3. XM_017007662.1XP_016863151.1  serine/threonine-protein kinase PLK4 isoform X1

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