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CFL1 cofilin 1 [ Homo sapiens (human) ]

Gene ID: 1072, updated on 5-Jul-2020

Summary

Official Symbol
CFL1provided by HGNC
Official Full Name
cofilin 1provided by HGNC
Primary source
HGNC:HGNC:1874
See related
Ensembl:ENSG00000172757 MIM:601442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CFL; cofilin; HEL-S-15
Summary
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in duodenum (RPKM 413.9), colon (RPKM 411.4) and 25 other tissues See more
Orthologs

Genomic context

See CFL1 in Genome Data Viewer
Location:
11q13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65854673..65858180, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65622282..65625804, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 5 subunit beta 1 Neighboring gene OVOL1 antisense RNA 1 Neighboring gene ovo like transcriptional repressor 1 Neighboring gene sorting nexin 32 Neighboring gene MUS81 structure-specific endonuclease subunit Neighboring gene EGF containing fibulin extracellular matrix protein 2 Neighboring gene cathepsin W Neighboring gene FGF1 intracellular binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
NHGRI GWA Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env CCR5 expression inhibits HIV-1 gp120-induced LIMK1 activation and cofilin phosphorylation in CD4/CXCR4 expressing 293T cells PubMed
env HIV-1 gp120-CXCR4 signaling triggers cofilin activation and actin reorganization, which are important for a post entry process leading to viral nuclear localization PubMed
env The N-terminal leucine-rich repeat fragment of Slit2 inhibits HIV-1 gp120-induced phosphorylation of both LIMK1 and cofilin PubMed
env Filamin-A-dependent activation of the RhoA-ROCK-LIMK-cofilin pathway is a major event in HIV-1 gp120-induced receptor clustering PubMed
Nef nef HIV-1 Nef-induced LIMK1 activation and CFL1 phosphorylation are required for Nef-mediated inhibition of retinoid receptor function PubMed
nef The HIV-1 Nef highly conserved valine-glycine-phenylalanine amino acid triplet (VGF) motif is important for Nef-PAK2 association and cofillin hyper-phosphorylation PubMed
nef HIV-1 Nef inactivates cofilin by inducing its hyperphosphorylation via association with PAK2 activity PubMed
Pr55(Gag) gag The cytoskeletal proteins ezrin, moesin, and cofilin are incorporated into HIV-1 particles, presumably through their interaction with actin which binds to the nucleocapsid domain of HIV-1 Gag PubMed
Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Rho protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
actin filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament depolymerization NAS
Non-traceable Author Statement
more info
PubMed 
actin filament fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
neural fold formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation by host of viral process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to amino acid IEA
Inferred from Electronic Annotation
more info
 
response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
focal adhesion HDA PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
vesicle HDA PubMed 

General protein information

Preferred Names
cofilin-1
Names
18 kDa phosphoprotein
cofilin 1 (non-muscle)
cofilin, non-muscle isoform
epididymis secretory protein Li 15
p18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005507.3NP_005498.1  cofilin-1

    See identical proteins and their annotated locations for NP_005498.1

    Status: REVIEWED

    Source sequence(s)
    AK097690, AP001266, BC018256, CB850882
    Consensus CDS
    CCDS8114.1
    UniProtKB/Swiss-Prot
    P23528
    UniProtKB/TrEMBL
    V9HWI5
    Related
    ENSP00000309629.5, ENST00000308162.10
    Conserved Domains (1) summary
    cd11286
    Location:3153
    ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65854673..65858180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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