U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

INSR insulin receptor [ Equus asinus (ass) ]

Gene ID: 106844524, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
INSR
Gene description
insulin receptor
See related
Ensembl:ENSEASG00005013740
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus asinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 20
Exon count:
22
Annotation release Status Assembly Chr Location
101 current ASM1607732v2 (GCF_016077325.2) 20 NC_052196.1 (5070957..5198602, complement)
100 previous assembly ASM130575v1 (GCF_001305755.1) Unplaced Scaffold NW_014638256.1 (1125162..1251900)

Chromosome 20 - NC_052196.1Genomic Context describing neighboring genes Neighboring gene vomeronasal type-2 receptor 116-like Neighboring gene zinc finger protein 558-like Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene peroxisomal biogenesis factor 11 gamma

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
insulin receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Equus asinus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1607732v2

Genomic

  1. NC_052196.1 Reference ASM1607732v2

    Range
    5070957..5198602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_044753125.1 → XP_044609060.1  insulin receptor isoform X4

    Conserved Domains (5) summary
    cd05061
    Location:1003 → 1290
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:855 → 932
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:928 → 974
    Insulin_TMD; Insulin receptor trans-membrane segment

  2. XM_044753124.1 → XP_044609059.1  insulin receptor isoform X3

    UniProtKB/TrEMBL
    A0A8C4M284
    Related
    ENSEASP00005019926.2, ENSEAST00005021638.2
    Conserved Domains (5) summary
    cd05061
    Location:1004 → 1291
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:855 → 932
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:928 → 975
    Insulin_TMD; Insulin receptor trans-membrane segment

  3. XM_014862015.2 → XP_014717501.2  insulin receptor isoform X2

    Conserved Domains (5) summary
    cd05061
    Location:1015 → 1302
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:867 → 944
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:940 → 986
    Insulin_TMD; Insulin receptor trans-membrane segment

  4. XM_044753123.1 → XP_044609058.1  insulin receptor isoform X1

    UniProtKB/TrEMBL
    A0A8C4M0K9
    Related
    ENSEASP00005019921.2, ENSEAST00005021631.2
    Conserved Domains (5) summary
    cd05061
    Location:1016 → 1303
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:867 → 944
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:940 → 987
    Insulin_TMD; Insulin receptor trans-membrane segment
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.