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Insr insulin receptor [ Mus musculus (house mouse) ]

Gene ID: 16337, updated on 17-Jul-2018
Official Symbol
Insrprovided by MGI
Official Full Name
insulin receptorprovided by MGI
Primary source
MGI:MGI:96575
See related
Ensembl:ENSMUSG00000005534 Vega:OTTMUSG00000031438
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik
Summary
This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in heart adult (RPKM 8.5), adrenal adult (RPKM 7.8) and 28 other tissues See more
Orthologs
See Insr in Genome Data Viewer
Location:
8 A1.1; 8 1.82 cM
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (3150922..3279649, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (3150922..3279617, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 384 pseudogene Neighboring gene vomeronasal 2, receptor, pseudogene 88 Neighboring gene RIKEN cDNA A430078G23 gene Neighboring gene predicted gene, 30369 Neighboring gene rho/rac guanine nucleotide exchange factor (GEF) 18 Neighboring gene predicted gene, 46029

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (3) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3-phosphoinositide-dependent protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
GTP binding ISO
Inferred from Sequence Orthology
more info
 
MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PTB domain binding ISO
Inferred from Sequence Orthology
more info
 
amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
insulin binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor substrate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor substrate binding ISO
Inferred from Sequence Orthology
more info
 
insulin-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor II binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
lipoic acid binding ISO
Inferred from Sequence Orthology
more info
 
mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
adrenal gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
male gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
male sex determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transporter activity ISO
Inferred from Sequence Orthology
more info
 
neuron projection maintenance ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of developmental growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of meiotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein complex disassembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of respiratory burst ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
 
regulation of female gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of hydrogen peroxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
transformation of host cell by virus ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
caveola ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
insulin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor complex ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nuclear lumen ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
insulin receptor
NP_034698.2
XP_006508762.1
XP_006508763.1
XP_006508764.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330056.1NP_001316985.1  insulin receptor isoform B preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform B which is longer than isoform A.
    Source sequence(s)
    AC168068, BY733217, KC356871
    UniProtKB/TrEMBL
    M4TKR7
    Conserved Domains (6) summary
    cd05061
    Location:10181305
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:869946
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:234281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359472
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:10251292
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_010568.3NP_034698.2  insulin receptor isoform A preproprotein

    See identical proteins and their annotated locations for NP_034698.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform A).
    Source sequence(s)
    AC168068, AK077054, AK164267, BY733217, J05149
    Consensus CDS
    CCDS22059.1
    UniProtKB/Swiss-Prot
    P15208
    UniProtKB/TrEMBL
    Q3TPM5
    Related
    ENSMUSP00000088837.4, OTTMUSP00000041297, ENSMUST00000091291.4, OTTMUST00000077897
    Conserved Domains (6) summary
    cd05061
    Location:10061293
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:857934
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:234281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359472
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:10131280
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    3150922..3279649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508701.1XP_006508764.1  insulin receptor isoform X3

    Conserved Domains (6) summary
    cd05061
    Location:10051292
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:857934
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:234281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359472
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:10121279
    Pkinase_Tyr; Protein tyrosine kinase
  2. XM_006508700.1XP_006508763.1  insulin receptor isoform X2

    Conserved Domains (6) summary
    cd05061
    Location:10171304
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:869946
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:234281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359472
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:10241291
    Pkinase_Tyr; Protein tyrosine kinase
  3. XM_006508699.1XP_006508762.1  insulin receptor isoform X1

    Conserved Domains (6) summary
    cd05061
    Location:10181305
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:869946
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:234281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359472
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:10251292
    Pkinase_Tyr; Protein tyrosine kinase
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