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TNFSF13B TNF superfamily member 13b [ Homo sapiens (human) ]

Gene ID: 10673, updated on 17-Sep-2024

Summary

Official Symbol
TNFSF13Bprovided by HGNC
Official Full Name
TNF superfamily member 13bprovided by HGNC
Primary source
HGNC:HGNC:11929
See related
Ensembl:ENSG00000102524 MIM:603969; AllianceGenome:HGNC:11929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNLG7A; TNFSF20
Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Expression
Broad expression in appendix (RPKM 11.4), lymph node (RPKM 7.1) and 21 other tissues See more
Orthologs
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Genomic context

See TNFSF13B in Genome Data Viewer
Location:
13q33.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (108269629..108308484)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (107496022..107535489)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (108921977..108960832)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5495 Neighboring gene DNA ligase 4 Neighboring gene abhydrolase domain containing 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:108922483-108922991 Neighboring gene RNA, 5S ribosomal pseudogene 39 Neighboring gene NANOG hESC enhancer GRCh37_chr13:108978967-108979599 Neighboring gene uncharacterized LOC105370355 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32209 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32236 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32244 Neighboring gene host cell factor C2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 cooperates with BAFF and cytokines IL-4 and IL-10 to activate mannose C-type lectin receptors-expressing B cells PubMed
Nef nef HIV-1 Nef upregulates levels of B lymphocyte stimulator (BLyS) expression in monocyte-derived DCs PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tumor necrosis factor superfamily, member 13b (TNFSF13B) in primary human brain microvascular endothelial cells PubMed
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that TNFSF13B gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with TNFSF13B PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell costimulation IEA
Inferred from Electronic Annotation
more info
 
involved_in B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell costimulation IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in germinal center formation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of B cell proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of germinal center formation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in skin development IEA
Inferred from Electronic Annotation
more info
 
involved_in transitional one stage B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tumor necrosis factor ligand superfamily member 13B
Names
ApoL related ligand TALL-1
B-cell-activating factor
B-lymphocyte stimulator
Delta4 BAFF
TNF and ApoL-related leukocyte expressed ligand 1
TNF homolog that activates apoptosis
delta BAFF
dendritic cell-derived TNF-like molecule
epididymis secretory sperm binding protein
tumor necrosis factor (ligand) superfamily, member 13b
tumor necrosis factor (ligand) superfamily, member 20
tumor necrosis factor ligand 7A
tumor necrosis factor superfamily member 13b
tumor necrosis factor-like protein ZTNF4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029524.1 RefSeqGene

    Range
    5090..43850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145645.2NP_001139117.1  tumor necrosis factor ligand superfamily member 13B isoform 2

    See identical proteins and their annotated locations for NP_001139117.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) omits an in-frame coding exon, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AL157762, AY302751, BI818459, BQ778438
    Consensus CDS
    CCDS45067.1
    UniProtKB/Swiss-Prot
    Q9Y275
    Related
    ENSP00000389540.1, ENST00000430559.5
    Conserved Domains (1) summary
    cd00184
    Location:135263
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
  2. NM_006573.5NP_006564.1  tumor necrosis factor ligand superfamily member 13B isoform 1

    See identical proteins and their annotated locations for NP_006564.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents a longer transcript and encodes the longer protein isoform (1).
    Source sequence(s)
    AL157762
    Consensus CDS
    CCDS9509.1
    UniProtKB/Swiss-Prot
    E0ADT7, Q6FHD6, Q7Z5J2, Q9Y275
    UniProtKB/TrEMBL
    A0A0U5J7Q1
    Related
    ENSP00000365048.3, ENST00000375887.9
    Conserved Domains (1) summary
    cd00184
    Location:146282
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    108269629..108308484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430055.1XP_047286011.1  tumor necrosis factor ligand superfamily member 13B isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    107496022..107535489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374034.1XP_054230009.1  tumor necrosis factor ligand superfamily member 13B isoform X1