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CXCR6 C-X-C motif chemokine receptor 6 [ Homo sapiens (human) ]

Gene ID: 10663, updated on 21-Jun-2020

Summary

Official Symbol
CXCR6provided by HGNC
Official Full Name
C-X-C motif chemokine receptor 6provided by HGNC
Primary source
HGNC:HGNC:16647
See related
Ensembl:ENSG00000172215 MIM:605163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BONZO; CD186; STRL33; TYMSTR
Expression
Broad expression in lymph node (RPKM 5.9), spleen (RPKM 4.9) and 19 other tissues See more
Orthologs

Genomic context

See CXCR6 in Genome Data Viewer
Location:
3p21.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (45940688..45948354)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45984973..45989845)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene leucine zipper transcription factor like 1 Neighboring gene succinate dehydrogenase complex subunit D pseudogene 4 Neighboring gene C-C motif chemokine receptor 9 Neighboring gene FYVE and coiled-coil domain autophagy adaptor 1 Neighboring gene uncharacterized LOC105377063 Neighboring gene nuclear receptor binding factor 2 pseudogene 2 Neighboring gene X-C motif chemokine receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Macrophage-tropic HIV-1 can use CCR2b, and to a lesser extent CCR3, STRL33, and APJ, to infect cells; the V1/2 region of HIV-1 gp120 plays a more important role in governing the use of CCR2b, CCR3, STRL33, and APJ than for CXCR4 PubMed
env Some HIV-1 isolates are able to use CCR5/Bonzo as HIV-1 gp120 coreceptors for entry into cells PubMed
env Coexpression of DC-SIGN enables some HIV-1 isolates to use alternate HIV-1 gp120 coreceptors like STRL33 to infect cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-X-C chemokine binding IEA
Inferred from Electronic Annotation
more info
 
C-X-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coreceptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral genome replication TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 6
Names
CDw186
CXC-R6
CXCR-6
G protein-coupled receptor
G-protein coupled receptor STRL33
G-protein coupled receptor bonzo
chemokine (C-X-C motif) receptor 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006564.2NP_006555.1  C-X-C chemokine receptor type 6

    See identical proteins and their annotated locations for NP_006555.1

    Status: VALIDATED

    Source sequence(s)
    AC099782, Y13248
    Consensus CDS
    CCDS2735.1
    UniProtKB/Swiss-Prot
    O00574
    UniProtKB/TrEMBL
    A0N0N3
    Related
    ENSP00000304414.4, ENST00000304552.5
    Conserved Domains (1) summary
    cd15173
    Location:32299
    7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    45940688..45948354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533290.2XP_011531592.1  C-X-C chemokine receptor type 6 isoform X1

    See identical proteins and their annotated locations for XP_011531592.1

    UniProtKB/Swiss-Prot
    O00574
    UniProtKB/TrEMBL
    A0N0N3
    Conserved Domains (1) summary
    cd15173
    Location:32299
    7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_011533291.2XP_011531593.1  C-X-C chemokine receptor type 6 isoform X1

    See identical proteins and their annotated locations for XP_011531593.1

    UniProtKB/Swiss-Prot
    O00574
    UniProtKB/TrEMBL
    A0N0N3
    Related
    ENSP00000396218.1, ENST00000438735.1
    Conserved Domains (1) summary
    cd15173
    Location:32299
    7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_005264809.2XP_005264866.1  C-X-C chemokine receptor type 6 isoform X1

    See identical proteins and their annotated locations for XP_005264866.1

    UniProtKB/Swiss-Prot
    O00574
    UniProtKB/TrEMBL
    A0N0N3
    Related
    ENSP00000396886.1, ENST00000457814.1
    Conserved Domains (1) summary
    cd15173
    Location:32299
    7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
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