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RGS14 regulator of G protein signaling 14 [ Homo sapiens (human) ]

Gene ID: 10636, updated on 12-Oct-2019

Summary

Official Symbol
RGS14provided by HGNC
Official Full Name
regulator of G protein signaling 14provided by HGNC
Primary source
HGNC:HGNC:9996
See related
Ensembl:ENSG00000169220 MIM:602513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 15.0), lymph node (RPKM 11.5) and 23 other tissues See more
Orthologs

Genomic context

See RGS14 in Genome Data Viewer
Location:
5q35.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (177357672..177372601)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176784704..176799599)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 1 Neighboring gene MAX dimerization protein 3 Neighboring gene lectin, mannose binding 2 Neighboring gene ribosomal protein S20 pseudogene 17 Neighboring gene VISTA enhancer hs2229 Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.
NHGRI GWA Catalog
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
NHGRI GWA Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
NHGRI GWA Catalog
New loci associated with kidney function and chronic kidney disease.
NHGRI GWA Catalog

Pathways from BioSystems

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
 
GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activating protein binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
receptor signaling complex scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
learning ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleocytoplasmic transport ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet-derived growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA-templated transcription in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
visual learning ISS
Inferred from Sequence or Structural Similarity
more info
 
zygote asymmetric cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
nuclear body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
spindle IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366617.1NP_001353546.1  regulator of G-protein signaling 14 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC146507
    Conserved Domains (5) summary
    smart00455
    Location:376445
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:303376
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08743
    Location:58186
    RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
    smart00390
    Location:499521
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam16613
    Location:189273
    RGS12_us1; Unstructured region of RGS12
  2. NM_001366618.1NP_001353547.1  regulator of G-protein signaling 14 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC146507
  3. NM_006480.5NP_006471.2  regulator of G-protein signaling 14 isoform 1

    See identical proteins and their annotated locations for NP_006471.2

    Status: REVIEWED

    Source sequence(s)
    BC014094
    Consensus CDS
    CCDS43405.1
    UniProtKB/Swiss-Prot
    O43566
    Related
    ENSP00000386229.3, ENST00000408923.8
    Conserved Domains (4) summary
    smart00455
    Location:375444
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:303375
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08743
    Location:58186
    RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
    smart00390
    Location:498520
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    177357672..177372601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454328.1XP_024310096.1  regulator of G-protein signaling 14 isoform X1

    Conserved Domains (5) summary
    smart00455
    Location:376445
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:303376
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08743
    Location:58186
    RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
    smart00390
    Location:525547
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam16613
    Location:189273
    RGS12_us1; Unstructured region of RGS12
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