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Rgs14 regulator of G-protein signaling 14 [ Mus musculus (house mouse) ]

Gene ID: 51791, updated on 21-Oct-2019

Summary

Official Symbol
Rgs14provided by MGI
Official Full Name
regulator of G-protein signaling 14provided by MGI
Primary source
MGI:MGI:1859709
See related
Ensembl:ENSMUSG00000052087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPIP1
Expression
Biased expression in thymus adult (RPKM 63.5), spleen adult (RPKM 29.2) and 7 other tissues See more
Orthologs

Genomic context

See Rgs14 in Genome Data Viewer
Location:
13 B1; 13 29.8 cM
Exon count:
15
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55369732..55384687)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55471093..55486048)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 1 Neighboring gene Max dimerization protein 3 Neighboring gene lectin, mannose-binding 2 Neighboring gene solute carrier family 34 (sodium phosphate), member 1 Neighboring gene profilin 3 Neighboring gene coagulation factor XII (Hageman factor)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
receptor signaling complex scaffold activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division ISO
Inferred from Sequence Orthology
more info
 
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term synaptic potentiation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA-templated transcription in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle organization ISO
Inferred from Sequence Orthology
more info
 
visual learning ISO
Inferred from Sequence Orthology
more info
 
zygote asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
spindle IDA
Inferred from Direct Assay
more info
PubMed 
spindle ISO
Inferred from Sequence Orthology
more info
 
spindle pole ISO
Inferred from Sequence Orthology
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 14
Names
RAP1/RAP2-interacting protein
rap1/rap2 interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360714.1NP_001347643.1  regulator of G-protein signaling 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT009762
    Conserved Domains (3) summary
    cd01817
    Location:304377
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08743
    Location:58186
    RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
    cl25424
    Location:385445
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  2. NM_016758.3NP_058038.2  regulator of G-protein signaling 14 isoform 1

    See identical proteins and their annotated locations for NP_058038.2

    Status: VALIDATED

    Source sequence(s)
    CT009762
    Consensus CDS
    CCDS36674.1
    UniProtKB/Swiss-Prot
    P97492
    Related
    ENSMUSP00000068731.7, ENSMUST00000063771.13
    Conserved Domains (4) summary
    cd01817
    Location:304377
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08743
    Location:58186
    RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
    smart00390
    Location:500522
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cl00155
    Location:385445
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p6 C57BL/6J

    Range
    55369732..55384687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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