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POSTN periostin [ Homo sapiens (human) ]

Gene ID: 10631, updated on 17-Jun-2018
Official Symbol
POSTNprovided by HGNC
Official Full Name
periostinprovided by HGNC
Primary source
HGNC:HGNC:16953
See related
Ensembl:ENSG00000133110 MIM:608777; Vega:OTTHUMG00000016751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PN; OSF2; OSF-2; PDLPOSTN
Summary
This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Broad expression in skin (RPKM 83.7), urinary bladder (RPKM 52.8) and 14 other tissues See more
Orthologs
See POSTN in Genome Data Viewer
Location:
13q13.3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (37562582..37598844, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (38136719..38172981, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1048 Neighboring gene long intergenic non-protein coding RNA 547 Neighboring gene transient receptor potential cation channel subfamily C member 4 Neighboring gene RNA, 5S ribosomal pseudogene 26 Neighboring gene long intergenic non-protein coding RNA 2334 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 9

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.
NHGRI GWA Catalog
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced downregulation of periostin, osteoblast specific factor (POSTN) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC119510, MGC119511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
bone regeneration IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to fibroblast growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to vitamin K IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemokine (C-C motif) ligand 2 secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to muscle activity IEA
Inferred from Electronic Annotation
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
periostin
Names
osteoblast specific factor 2 (fasciclin I-like)
periodontal ligament-specific periostin
periostin, osteoblast specific factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135934.1NP_001129406.1  periostin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001129406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI580215, BC106710, BG938993, DC403736
    Consensus CDS
    CCDS45034.1
    UniProtKB/Swiss-Prot
    Q15063
    UniProtKB/TrEMBL
    A0A024RDT5
    Related
    ENSP00000369066.4, OTTHUMP00000018269, ENST00000379742.4, OTTHUMT00000044567
    Conserved Domains (1) summary
    pfam02469
    Location:245367
    Fasciclin; Fasciclin domain
  2. NM_001135935.1NP_001129407.1  periostin isoform 3 precursor

    See identical proteins and their annotated locations for NP_001129407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (3, also known as thy6) is shorter than isoform 1.
    Source sequence(s)
    AI580215, AY140646, BQ575951, DC403736
    Consensus CDS
    CCDS53864.1
    UniProtKB/Swiss-Prot
    Q15063
    Related
    ENSP00000437959.1, ENST00000541179.5
    Conserved Domains (1) summary
    pfam02469
    Location:245367
    Fasciclin; Fasciclin domain
  3. NM_001135936.1NP_001129408.1  periostin isoform 4 precursor

    See identical proteins and their annotated locations for NP_001129408.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AI580215, AY918092, BP335818, BQ575951, BY795054, DC403736
    UniProtKB/Swiss-Prot
    Q15063
    Conserved Domains (1) summary
    pfam02469
    Location:245367
    Fasciclin; Fasciclin domain
  4. NM_001286665.1NP_001273594.1  periostin isoform 5 precursor

    See identical proteins and their annotated locations for NP_001273594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (5, also known as thy2) is shorter than isoform 1.
    Source sequence(s)
    AI580215, AY140646, BQ575951, DC403736, EU262883
    Consensus CDS
    CCDS66531.1
    UniProtKB/Swiss-Prot
    Q15063
    Related
    ENSP00000369067.4, OTTHUMP00000018270, ENST00000379743.8, OTTHUMT00000044568
    Conserved Domains (1) summary
    pfam02469
    Location:245367
    Fasciclin; Fasciclin domain
  5. NM_001286666.1NP_001273595.1  periostin isoform 6 precursor

    See identical proteins and their annotated locations for NP_001273595.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (6, also known as thy4) is shorter than isoform 1.
    Source sequence(s)
    AI580215, AY140646, BQ575951, DC403736, EU262884
    Consensus CDS
    CCDS66530.1
    UniProtKB/Swiss-Prot
    Q15063
    Related
    ENSP00000437953.1, ENST00000541481.5
    Conserved Domains (1) summary
    pfam02469
    Location:245367
    Fasciclin; Fasciclin domain
  6. NM_001286667.1NP_001273596.1  periostin isoform 7 precursor

    See identical proteins and their annotated locations for NP_001273596.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks four alternate in-frame exons, compared to variant 1. The encoded isoform (7, also known as thy8) is shorter than isoform 1.
    Source sequence(s)
    AI580215, AY140646, BQ575951, DC403736, EU262886
    UniProtKB/Swiss-Prot
    Q15063
    Conserved Domains (1) summary
    pfam02469
    Location:245367
    Fasciclin; Fasciclin domain
  7. NM_001330517.1NP_001317446.1  periostin isoform 8 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (8) is shorter than isoform 1.
    Source sequence(s)
    AI580215, BC106709, BQ575951, DC403736, JG969042
    Consensus CDS
    CCDS81764.1
    UniProtKB/Swiss-Prot
    Q15063
    UniProtKB/TrEMBL
    B1ALD9
    Related
    ENSP00000369073.4, ENST00000379749.8
  8. NM_006475.2NP_006466.2  periostin isoform 1 precursor

    See identical proteins and their annotated locations for NP_006466.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI580215, BC106709, BQ575951, D13666, DC403736
    Consensus CDS
    CCDS9364.1
    UniProtKB/Swiss-Prot
    Q15063
    UniProtKB/TrEMBL
    A0A024RDS2
    Related
    ENSP00000369071.4, OTTHUMP00000018268, ENST00000379747.8, OTTHUMT00000044566
    Conserved Domains (1) summary
    pfam02469
    Location:245367
    Fasciclin; Fasciclin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    37562582..37598844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266232.2XP_005266289.1  periostin isoform X3

    Conserved Domains (1) summary
    pfam02469
    Location:245367
    Fasciclin; Fasciclin domain
  2. XM_017020355.1XP_016875844.1  periostin isoform X1

  3. XM_017020356.1XP_016875845.1  periostin isoform X2

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