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IVNS1ABP influenza virus NS1A binding protein [ Homo sapiens (human) ]

Gene ID: 10625, updated on 6-Sep-2022

Summary

Official Symbol
IVNS1ABPprovided by HGNC
Official Full Name
influenza virus NS1A binding proteinprovided by HGNC
Primary source
HGNC:HGNC:16951
See related
Ensembl:ENSG00000116679 MIM:609209; AllianceGenome:HGNC:16951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ND1; ARA3; NS-1; IMD70; NS1BP; FLARA3; KLHL39; NS1-BP; HSPC068
Summary
Involved in RNA splicing; negative regulation of protein ubiquitination; and response to virus. Located in cytosol. Implicated in immunodeficiency 70. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 56.1), kidney (RPKM 31.5) and 24 other tissues See more
Orthologs
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Genomic context

See IVNS1ABP in Genome Data Viewer
Location:
1q25.3
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (185296388..185317243, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (184653292..184674147, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (185265520..185286375, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SWT1 RNA endoribonuclease homolog Neighboring gene ribosomal protein L5 pseudogene 5 Neighboring gene uncharacterized LOC105371651 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 pseudogene Neighboring gene microtubule associated protein 1 light chain 3 beta pseudogene Neighboring gene CBS mRNA stabilizing lncRNA Neighboring gene Sharpr-MPRA regulatory region 834

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with influenza virus NS1A binding protein (IVNS1ABP; NS1BP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10069, FLJ10411, FLJ10962, FLJ35593, FLJ36593, KIAA0850, DKFZp686K06216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex TAS
Traceable Author Statement
more info
PubMed 
part_of transcription regulator complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
influenza virus NS1A-binding protein
Names
NCX downstream gene 1
NS1-binding protein
aryl hydrocarbon receptor-associated 3
aryl hydrocarbon receptor-associated protein 3
kelch-like family member 39
kelch-like protein 39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006469.5NP_006460.2  influenza virus NS1A-binding protein

    See identical proteins and their annotated locations for NP_006460.2

    Status: VALIDATED

    Source sequence(s)
    AB020657, AF205218, AK000931, AL137640
    Consensus CDS
    CCDS1368.1
    UniProtKB/Swiss-Prot
    Q9Y480, Q9Y6Y0
    Related
    ENSP00000356468.3, ENST00000367498.8
    Conserved Domains (4) summary
    PHA03098
    Location:23638
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:502545
    Kelch; KELCH repeat [structural motif]
    cd18306
    Location:14137
    BTB_POZ_NS1BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP)
    cd18502
    Location:129225
    BACK_NS1BP_IVNS1ABP; BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    185296388..185317243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434096.1XP_047290052.1  influenza virus NS1A-binding protein isoform X2

  2. XM_047434070.1XP_047290026.1  influenza virus NS1A-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q9Y480
  3. XM_047434109.1XP_047290065.1  influenza virus NS1A-binding protein isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    184653292..184674147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016389.2: Suppressed sequence

    Description
    NM_016389.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.