Format

Send to:

Choose Destination

IVNS1ABP influenza virus NS1A binding protein [ Homo sapiens (human) ]

Gene ID: 10625, updated on 12-Oct-2019

Summary

Official Symbol
IVNS1ABPprovided by HGNC
Official Full Name
influenza virus NS1A binding proteinprovided by HGNC
Primary source
HGNC:HGNC:16951
See related
Ensembl:ENSG00000116679 MIM:609209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ND1; ARA3; NS-1; NS1BP; FLARA3; KLHL39; NS1-BP; HSPC068
Expression
Ubiquitous expression in bone marrow (RPKM 56.1), kidney (RPKM 31.5) and 24 other tissues See more
Orthologs

Genomic context

See IVNS1ABP in Genome Data Viewer
Location:
1q25.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (185292367..185317292, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (185265520..185286461, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SWT1 RNA endoribonuclease homolog Neighboring gene ribosomal protein L5 pseudogene 5 Neighboring gene uncharacterized LOC105371651 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 pseudogene Neighboring gene microtubule associated protein 1 light chain 3 beta pseudogene Neighboring gene uncharacterized LOC107985455

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with influenza virus NS1A binding protein (IVNS1ABP; NS1BP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10069, FLJ10411, FLJ10962, FLJ35593, FLJ36593, KIAA0850, DKFZp686K06216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription by RNA polymerase III TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
spliceosomal complex TAS
Traceable Author Statement
more info
PubMed 
transcription factor complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
influenza virus NS1A-binding protein
Names
NCX downstream gene 1
NS1-binding protein
aryl hydrocarbon receptor-associated 3
aryl hydrocarbon receptor-associated protein 3
kelch-like family member 39
kelch-like protein 39

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006469.5NP_006460.2  influenza virus NS1A-binding protein

    See identical proteins and their annotated locations for NP_006460.2

    Status: VALIDATED

    Source sequence(s)
    AB020657, AF205218, AK000931, AL137640
    Consensus CDS
    CCDS1368.1
    UniProtKB/Swiss-Prot
    Q9Y6Y0
    Related
    ENSP00000356468.3, ENST00000367498.8
    Conserved Domains (2) summary
    sd00038
    Location:502545
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:23638
    BTB; Broad-Complex, Tramtrack and Bric a brac

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    185292367..185317292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509080.3XP_011507382.1  influenza virus NS1A-binding protein isoform X2

    Conserved Domains (4) summary
    smart00612
    Location:432477
    Kelch; Kelch domain
    smart00875
    Location:45140
    BACK; BTB And C-terminal Kelch
    sd00038
    Location:420463
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:513553
    Kelch_1; Kelch motif
  2. XM_011509079.3XP_011507381.1  influenza virus NS1A-binding protein isoform X1

    Conserved Domains (6) summary
    smart00612
    Location:521566
    Kelch; Kelch domain
    smart00875
    Location:134229
    BACK; BTB And C-terminal Kelch
    PHA03098
    Location:23645
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:509552
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:22126
    BTB; BTB/POZ domain
    pfam01344
    Location:602642
    Kelch_1; Kelch motif
  3. XM_005244843.3XP_005244900.1  influenza virus NS1A-binding protein isoform X4

    Conserved Domains (3) summary
    smart00612
    Location:296341
    Kelch; Kelch domain
    sd00038
    Location:284327
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:377417
    Kelch_1; Kelch motif
  4. XM_017000084.1XP_016855573.1  influenza virus NS1A-binding protein isoform X3

    Conserved Domains (3) summary
    smart00612
    Location:303348
    Kelch; Kelch domain
    sd00038
    Location:291334
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:384424
    Kelch_1; Kelch motif

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016389.2: Suppressed sequence

    Description
    NM_016389.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center