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POLR3C RNA polymerase III subunit C [ Homo sapiens (human) ]

Gene ID: 10623, updated on 9-Sep-2018

Summary

Official Symbol
POLR3Cprovided by HGNC
Official Full Name
RNA polymerase III subunit Cprovided by HGNC
Primary source
HGNC:HGNC:30076
See related
Ensembl:ENSG00000186141 MIM:617454; Vega:OTTHUMG00000013753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPC3; RPC62
Expression
Ubiquitous expression in testis (RPKM 7.3), lymph node (RPKM 3.9) and 25 other tissues See more
Orthologs

Genomic context

See POLR3C in Genome Data Viewer
Location:
1q21.1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (145823183..145844402)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145592605..145610972, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 89A Neighboring gene PDZ domain containing 1 Neighboring gene CD160 molecule Neighboring gene ring finger protein 115 Neighboring gene nudix hydrolase 17 Neighboring gene microRNA 6736 Neighboring gene protein inhibitor of activated STAT 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-directed 5'-3' RNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase III TAS
Traceable Author Statement
more info
PubMed 
transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC3
Names
DNA-directed III 62 kDa polypeptide
DNA-directed RNA polymerase III subunit C
RNA polymerase III 62 kDa subunit
RNA polymerase III subunit C3
polymerase (RNA) III (DNA directed) polypeptide C (62kD)
polymerase (RNA) III subunit C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303456.1NP_001290385.1  DNA-directed RNA polymerase III subunit RPC3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an upstream start codon compared to variant 1. It encodes isoform 2 which has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC002586, BC053590, BE258456, BQ932484, DA291657, DA816269
    UniProtKB/Swiss-Prot
    Q9BUI4
    Conserved Domains (2) summary
    pfam05645
    Location:159358
    RNA_pol_Rpc82; RNA polymerase III subunit RPC82
    pfam08221
    Location:2078
    HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain
  2. NM_006468.7NP_006459.3  DNA-directed RNA polymerase III subunit RPC3 isoform 1

    See identical proteins and their annotated locations for NP_006459.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    BC002586, BC053590, BE258456, BI831011, BQ932484, DA291657
    Consensus CDS
    CCDS72864.1
    UniProtKB/Swiss-Prot
    Q9BUI4
    UniProtKB/TrEMBL
    A0A024R4C1
    Related
    ENSP00000334564.3, OTTHUMP00000015591, ENST00000334163.3, OTTHUMT00000038542
    Conserved Domains (2) summary
    pfam05645
    Location:146345
    RNA_pol_Rpc82; RNA polymerase III subunit RPC82
    pfam08221
    Location:765
    HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    145823183..145844402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272927.3XP_005272984.1  DNA-directed RNA polymerase III subunit RPC3 isoform X1

    See identical proteins and their annotated locations for XP_005272984.1

    Conserved Domains (1) summary
    pfam05645
    Location:29228
    RNA_pol_Rpc82; RNA polymerase III subunit RPC82
  2. XM_005272928.3XP_005272985.1  DNA-directed RNA polymerase III subunit RPC3 isoform X1

    See identical proteins and their annotated locations for XP_005272985.1

    Conserved Domains (1) summary
    pfam05645
    Location:29228
    RNA_pol_Rpc82; RNA polymerase III subunit RPC82
  3. XM_011509078.3XP_011507380.1  DNA-directed RNA polymerase III subunit RPC3 isoform X2

    Conserved Domains (2) summary
    pfam05645
    Location:159332
    RNA_pol_Rpc82; RNA polymerase III subunit RPC82
    pfam08221
    Location:2078
    HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

RNA

  1. XR_002958232.1 RNA Sequence

  2. XR_002958234.1 RNA Sequence

  3. XR_001736926.1 RNA Sequence

  4. XR_001736925.1 RNA Sequence

  5. XR_921720.3 RNA Sequence

  6. XR_921721.3 RNA Sequence

  7. XR_921722.3 RNA Sequence

  8. XR_921723.3 RNA Sequence

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