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btk Bruton agammaglobulinemia tyrosine kinase [ Fundulus heteroclitus (mummichog) ]

Gene ID: 105921135, updated on 13-Mar-2024

Summary

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Gene symbol
btk
Gene description
Bruton agammaglobulinemia tyrosine kinase
See related
Ensembl:ENSFHEG00000014022
Gene type
protein coding
RefSeq status
MODEL
Organism
Fundulus heteroclitus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Fundulidae; Fundulus
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 23
Exon count:
19
Annotation release Status Assembly Chr Location
102 current MU-UCD_Fhet_4.1 (GCF_011125445.2) 23 NC_046383.1 (2541573..2554870, complement)
101 previous assembly Fundulus_heteroclitus-3.0.2 (GCF_000826765.1) Unplaced Scaffold NW_012225096.1 (28816..41896, complement)

Chromosome 23 - NC_046383.1Genomic Context describing neighboring genes Neighboring gene Mg_trans_NIPA domain-containing protein Neighboring gene translocase of inner mitochondrial membrane 8 homolog A (yeast) Neighboring gene ribosomal protein L36A Neighboring gene galactosidase, alpha Neighboring gene uncharacterized LOC118557575

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase BTK
Names
Bruton tyrosine kinase
Tyrosine-protein kinase BTK

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Fundulus heteroclitus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference MU-UCD_Fhet_4.1 Primary Assembly

Genomic

  1. NC_046383.1 Reference MU-UCD_Fhet_4.1 Primary Assembly

    Range
    2541573..2554870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012856833.3 → XP_012712287.1  tyrosine-protein kinase BTK

    UniProtKB/TrEMBL
    A0A3Q2PIJ7, A0A3Q2QPN0
    Related
    ENSFHEP00000029349.1
    Conserved Domains (6) summary
    cd10397
    Location:253 → 356
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:195 → 249
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    cd01238
    Location:6 → 145
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam00169
    Location:5 → 112
    PH; PH domain
    pfam07714
    Location:379 → 625
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:374 → 630
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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