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IFI44 interferon induced protein 44 [ Homo sapiens (human) ]

Gene ID: 10561, updated on 3-May-2020

Summary

Official Symbol
IFI44provided by HGNC
Official Full Name
interferon induced protein 44provided by HGNC
Primary source
HGNC:HGNC:16938
See related
Ensembl:ENSG00000137965 MIM:610468
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p44; TLDC5; MTAP44
Expression
Broad expression in bone marrow (RPKM 19.2), spleen (RPKM 17.3) and 24 other tissues See more
Orthologs

Genomic context

See IFI44 in Genome Data Viewer
Location:
1p31.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (78648943..78664078)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (79115477..79129763)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene prostaglandin F receptor Neighboring gene interferon induced protein 44 like Neighboring gene ribosomal protein L23 pseudogene 3 Neighboring gene SNW domain containing 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of interferon-induced protein 44 (IFI44) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of interferon-inducible protein 44 (IFI44) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including MTAp44, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
response to virus TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interferon-induced protein 44
Names
TBC/LysM-associated domain containing 5
interferon-induced, hepatitis C-associated microtubular aggregate protein (44kD)
microtubule-associated protein 44

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006417.5NP_006408.3  interferon-induced protein 44

    See identical proteins and their annotated locations for NP_006408.3

    Status: VALIDATED

    Source sequence(s)
    BC022870, CA426666, DC300799, DN994910
    Consensus CDS
    CCDS688.1
    UniProtKB/Swiss-Prot
    Q8TCB0
    Related
    ENSP00000359783.4, ENST00000370747.9
    Conserved Domains (1) summary
    cl02144
    Location:2887
    TLD; TLD

RNA

  1. NR_135640.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI061108, AK316476, AL589497, BC022870
    Related
    ENST00000472152.5
  2. NR_135641.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI061108, AK316476, AL589497, BC022870

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    78648943..78664078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540516.3XP_011538818.1  interferon-induced protein 44 isoform X1

    Conserved Domains (1) summary
    cl02144
    Location:2870
    TLD; TLD
  2. XM_005270380.4XP_005270437.1  interferon-induced protein 44 isoform X3

    Conserved Domains (1) summary
    cl02144
    Location:2870
    TLD; TLD
  3. XM_017000083.2XP_016855572.1  interferon-induced protein 44 isoform X2

RNA

  1. XR_001736919.2 RNA Sequence

  2. XR_426586.4 RNA Sequence

  3. XR_001736922.2 RNA Sequence

  4. XR_001736920.2 RNA Sequence

  5. XR_001736921.2 RNA Sequence

  6. XR_001736923.2 RNA Sequence

  7. XR_001736924.2 RNA Sequence

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