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ARPC1A actin related protein 2/3 complex subunit 1A [ Homo sapiens (human) ]

Gene ID: 10552, updated on 7-Jun-2020

Summary

Official Symbol
ARPC1Aprovided by HGNC
Official Full Name
actin related protein 2/3 complex subunit 1Aprovided by HGNC
Primary source
HGNC:HGNC:703
See related
Ensembl:ENSG00000241685 MIM:604220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Arc40; SOP2L; HEL-68; SOP2Hs; HEL-S-307
Summary
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in thyroid (RPKM 48.9), stomach (RPKM 46.5) and 25 other tissues See more
Orthologs

Genomic context

See ARPC1A in Genome Data Viewer
Location:
7q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (99325873..99366262)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (98923496..98963885)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene karyopherin subunit alpha 7 Neighboring gene uncharacterized LOC105375421 Neighboring gene myosin heavy chain 16 pseudogene Neighboring gene Sharpr-MPRA regulatory region 4482 Neighboring gene actin related protein 2/3 complex subunit 1B Neighboring gene PDGFA associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of actin related protein 2/3 complex, subunit 1A, 41kDa (ARPC1A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding TAS
Traceable Author Statement
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 protein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
muscle cell projection membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
actin-related protein 2/3 complex subunit 1A
Names
SOP2-like protein
actin binding protein (Schizosaccharomyces pombe sop2-like)
actin related protein 2/3 complex, subunit 1A, 41kDa
epididymis luminal protein 68
epididymis secretory protein Li 307
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190996.1NP_001177925.1  actin-related protein 2/3 complex subunit 1A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks 2 nts at an alternate splice site in the 5' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    BC006445, DA089818
    Conserved Domains (3) summary
    COG2319
    Location:1351
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:4279
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:32274
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_006409.4NP_006400.2  actin-related protein 2/3 complex subunit 1A isoform 1

    See identical proteins and their annotated locations for NP_006400.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC039594, BC054027, DA089818
    Consensus CDS
    CCDS5660.1
    UniProtKB/Swiss-Prot
    Q92747
    UniProtKB/TrEMBL
    V9HVZ6
    Related
    ENSP00000262942.5, ENST00000262942.10
    Conserved Domains (2) summary
    sd00039
    Location:1150
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:46288
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    99325873..99366262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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