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IPO8 importin 8 [ Homo sapiens (human) ]

Gene ID: 10526, updated on 7-Jun-2020

Summary

Official Symbol
IPO8provided by HGNC
Official Full Name
importin 8provided by HGNC
Primary source
HGNC:HGNC:9853
See related
Ensembl:ENSG00000133704 MIM:605600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RANBP8
Summary
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in thyroid (RPKM 11.8), testis (RPKM 10.7) and 25 other tissues See more
Orthologs

Genomic context

See IPO8 in Genome Data Viewer
Location:
12p11.21
Exon count:
28
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (30628981..30695986, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (30781915..30848929, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369719 Neighboring gene uncharacterized LOC105369720 Neighboring gene caprin family member 2 Neighboring gene uncharacterized LOC645485

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21954, FLJ26580

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ran GTPase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
importin-8
Names
RAN binding protein 8
imp8
ran-binding protein 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190995.1NP_001177924.1  importin-8 isoform 2

    See identical proteins and their annotated locations for NP_001177924.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several 5' exons, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AA620453, AK130090, AK302260, BG574795, DB067822, DC400226, EB387074
    Consensus CDS
    CCDS53773.1
    UniProtKB/Swiss-Prot
    O15397
    Related
    ENSP00000444520.1, ENST00000544829.5
    Conserved Domains (2) summary
    COG5656
    Location:9791
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    pfam03378
    Location:536664
    CAS_CSE1; CAS/CSE protein, C-terminus
  2. NM_006390.4NP_006381.2  importin-8 isoform 1

    See identical proteins and their annotated locations for NP_006381.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK130090, AK302260, BG574795, DB067822, DB072643, DB088518, EB387074, U77494
    Consensus CDS
    CCDS8719.1
    UniProtKB/Swiss-Prot
    O15397
    Related
    ENSP00000256079.4, ENST00000256079.9
    Conserved Domains (3) summary
    COG5656
    Location:15996
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    pfam03378
    Location:741869
    CAS_CSE1; CAS/CSE protein, C-terminus
    pfam03810
    Location:22101
    IBN_N; Importin-beta N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    30628981..30695986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018691.2XP_016874180.1  importin-8 isoform X1

  2. XM_017018692.1XP_016874181.1  importin-8 isoform X2

  3. XM_017018693.2XP_016874182.1  importin-8 isoform X3

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