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Ipo8 importin 8 [ Mus musculus (house mouse) ]

Gene ID: 320727, updated on 5-Mar-2024

Summary

Official Symbol
Ipo8provided by MGI
Official Full Name
importin 8provided by MGI
Primary source
MGI:MGI:2444611
See related
Ensembl:ENSMUSG00000040029 AllianceGenome:MGI:2444611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Om1; MRP7; OM-1; Abcc10; Ranbp8; 6230418K12Rik; C130009K11Rik
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within protein transport. Predicted to be integral component of plasma membrane. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human IPO8 (importin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.3), bladder adult (RPKM 7.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
6 G3; 6 78.57 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (148672181..148732977, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148770683..148832931, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930528G23 gene Neighboring gene high mobility group box 1-like pseudogene Neighboring gene RIKEN cDNA 2610017A05 gene Neighboring gene STARR-positive B cell enhancer ABC_E1717 Neighboring gene caprin family member 2 Neighboring gene predicted gene, 36762

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase-coupled transmembrane transporter activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within transport ISA
Inferred from Sequence Alignment
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
PubMed 

General protein information

Preferred Names
importin-8
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
imp8
oocyte maturation 1
ran-binding protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081113.2NP_001074582.1  importin-8 isoform 1

    See identical proteins and their annotated locations for NP_001074582.1

    Status: VALIDATED

    Source sequence(s)
    AC134542
    Consensus CDS
    CCDS39719.1
    UniProtKB/Swiss-Prot
    B2KGD8, Q7TMY7, Q811I3, Q8C8A9, Q8R2P6, Q8R3V7
    Related
    ENSMUSP00000046759.8, ENSMUST00000048418.14
    Conserved Domains (3) summary
    COG5656
    Location:15995
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    pfam03378
    Location:626869
    CAS_CSE1; CAS/CSE protein, C-terminus
    pfam03810
    Location:22101
    IBN_N; Importin-beta N-terminal domain
  2. NM_001418294.1NP_001405223.1  importin-8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134542
  3. NM_001418295.1NP_001405224.1  importin-8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134542
  4. NM_001418296.1NP_001405225.1  importin-8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC134542

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    148672181..148732977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004942975.1 RNA Sequence