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ADARB2 adenosine deaminase RNA specific B2 (inactive) [ Homo sapiens (human) ]

Gene ID: 105, updated on 13-Mar-2020

Summary

Official Symbol
ADARB2provided by HGNC
Official Full Name
adenosine deaminase RNA specific B2 (inactive)provided by HGNC
Primary source
HGNC:HGNC:227
See related
Ensembl:ENSG00000185736 MIM:602065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RED2; ADAR3
Summary
This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 4.7), salivary gland (RPKM 0.5) and 3 other tissues See more
Orthologs

Genomic context

See ADARB2 in Genome Data Viewer
Location:
10p15.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (1177313..1737525, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (1223253..1779670, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376344 Neighboring gene long intergenic non-protein coding RNA 200 Neighboring gene uncharacterized LOC105376342 Neighboring gene ADARB2 antisense RNA 1 Neighboring gene uncharacterized LOC105376345 Neighboring gene uncharacterized LOC105376346

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
NHGRI GWA Catalog
Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 inhibits adenosine deaminase (ADA) binding to CD26 (dipeptidyl-peptidase 4) in both CD4+ and CD4- cells; this effect requires the interaction of gp120 with CD4 or CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25034, FLJ36975, FLJ41340

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
adenosine deaminase activity TAS
Traceable Author Statement
more info
PubMed 
double-stranded RNA adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded RNA binding TAS
Traceable Author Statement
more info
PubMed 
tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
double-stranded RNA-specific editase B2
Names
RED2 homolog
RNA-dependent adenosine deaminase 3
RNA-editing deaminase 2
RNA-editing enzyme 2
adenosine deaminase, RNA-specific, B2 (RED1 homolog rat)
adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)
adenosine deaminase, RNA-specific, B2 (non-functional)
dsRNA adenosine deaminase B2
homolog of rat BLUE

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018702.4NP_061172.1  double-stranded RNA-specific editase B2

    See identical proteins and their annotated locations for NP_061172.1

    Status: REVIEWED

    Source sequence(s)
    AC026224, AF034837, AL392083, BC140852
    Consensus CDS
    CCDS7058.1
    UniProtKB/Swiss-Prot
    Q9NS39
    Related
    ENSP00000370713.1, ENST00000381312.6
    Conserved Domains (2) summary
    smart00358
    Location:126188
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:361736
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    1177313..1737525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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