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ADARB2 adenosine deaminase RNA specific B2 (inactive) [ Homo sapiens (human) ]

Gene ID: 105, updated on 27-Nov-2024

Summary

Official Symbol
ADARB2provided by HGNC
Official Full Name
adenosine deaminase RNA specific B2 (inactive)provided by HGNC
Primary source
HGNC:HGNC:227
See related
Ensembl:ENSG00000185736 MIM:602065; AllianceGenome:HGNC:227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RED2; ADAR3
Summary
This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 4.7), salivary gland (RPKM 0.5) and 3 other tissues See more
Orthologs
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Genomic context

See ADARB2 in Genome Data Viewer
Location:
10p15.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (1177313..1737525, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (1174042..1734916, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (1223253..1779719, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1201744-1202634 Neighboring gene uncharacterized LOC105376344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1219106-1219608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1230396-1230996 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:1234984-1236183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1237029-1237528 Neighboring gene long intergenic non-protein coding RNA 200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1256314-1256814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1258172-1258702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1283673-1284184 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1284185-1284695 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:1297166-1297666 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:1297667-1298167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1312697-1313582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1313583-1314467 Neighboring gene MPRA-validated peak840 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1315089-1315589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1334566-1335464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1335779-1336688 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1351707-1352350 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1352996-1353639 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1354285-1354928 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1352351-1352995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1354929-1355573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1386449-1387132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2901 Neighboring gene uncharacterized LOC105376342 Neighboring gene Sharpr-MPRA regulatory region 10920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1421674-1422378 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1422379-1423081 Neighboring gene NANOG hESC enhancer GRCh37_chr10:1423311-1423822 Neighboring gene uncharacterized LOC124902364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1449419-1450003 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:1451683-1452882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1476825-1477620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1477621-1478414 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:1501805-1503004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1507617-1508326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1516725-1517244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1517245-1517763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2902 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:1531466-1531632 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:1541598-1542797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1564309-1564810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1571713-1572712 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:1576761-1577960 Neighboring gene ADARB2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1594399-1594926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1601202-1601702 Neighboring gene Sharpr-MPRA regulatory region 9114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1644395-1644901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1651053-1651582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1651583-1652110 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:1652312-1652473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1670265-1670764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1669763-1670264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1701309-1701862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1701863-1702414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1704841-1705340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1712437-1712938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1712939-1713438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1721606-1722106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1722107-1722607 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:1737450-1737614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1779051-1779647 Neighboring gene uncharacterized LOC105376345 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:1789244-1790443 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:1816736-1817445 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:1980919-1982118 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:1984230-1985429 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:2008580-2009779 Neighboring gene uncharacterized LOC105376346

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
EBI GWAS Catalog
Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 inhibits adenosine deaminase (ADA) binding to CD26 (dipeptidyl-peptidase 4) in both CD4+ and CD4- cells; this effect requires the interaction of gp120 with CD4 or CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ25034, FLJ36975, FLJ41340

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
double-stranded RNA-specific editase B2
Names
RED2 homolog
RNA-dependent adenosine deaminase 3
RNA-editing deaminase 2
RNA-editing enzyme 2
adenosine deaminase, RNA-specific, B2 (RED1 homolog rat)
adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)
adenosine deaminase, RNA-specific, B2 (non-functional)
dsRNA adenosine deaminase B2
homolog of rat BLUE

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018702.4NP_061172.1  double-stranded RNA-specific editase B2

    See identical proteins and their annotated locations for NP_061172.1

    Status: REVIEWED

    Source sequence(s)
    AC026224, AF034837, AL392083, BC140852
    Consensus CDS
    CCDS7058.1
    UniProtKB/Swiss-Prot
    B2RPJ5, Q5VUT6, Q5VW42, Q9NS39
    Related
    ENSP00000370713.1, ENST00000381312.6
    Conserved Domains (2) summary
    smart00358
    Location:126188
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:361736
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    1177313..1737525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    1174042..1734916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)