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CREB3 cAMP responsive element binding protein 3 [ Homo sapiens (human) ]

Gene ID: 10488, updated on 21-Jun-2020


Official Symbol
CREB3provided by HGNC
Official Full Name
cAMP responsive element binding protein 3provided by HGNC
Primary source
See related
Ensembl:ENSG00000107175 MIM:606443
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
Ubiquitous expression in prostate (RPKM 27.8), testis (RPKM 25.9) and 25 other tissues See more

Genomic context

See CREB3 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35732666..35736999)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35732317..35737005)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene skeletal muscle cis-regulatory module in TPM2 intron Neighboring gene tropomyosin 2 Neighboring gene talin 1 Neighboring gene microRNA 6852 Neighboring gene microRNA 6853 Neighboring gene glucosylceramidase beta 2 Neighboring gene RGP1 homolog, RAB6A GEF complex partner 1 Neighboring gene microseminoprotein, prostate associated Neighboring gene natriuretic peptide receptor 2 Neighboring gene sperm associated antigen 8

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cAMP responsive element binding protein 3 (CREB3; LZIP) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env The central region of luman (residues 100-314) and the residues 751 to 768 of HIV-1 gp41 are required for luman-Env interaction PubMed
env Interaction between the TMgp41 subunit of HIV-1 Env and Luman affects the stability of the full-length Luman protein PubMed
env Overexpression of Luman in cells transfected with HIV-1 provirus decreases the intracellular expression of Gag and Env and leads to a decrease in virion release PubMed
Pr55(Gag) gag Overexpression of Luman in cells transfected with HIV-1 provirus decreases the intracellular expression of Gag and Env and leads to a decrease in virion release PubMed
Tat tat Luman, a transcription factor of the CREB/ATF family, downregulates HIV-1 Tat-mediated transactivation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC15333, MGC19782

Gene Ontology Provided by GOA

Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
cytosol IDA
Inferred from Direct Assay
more info
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
integral component of membrane IEA
Inferred from Electronic Annotation
more info
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
nucleoplasm TAS
Traceable Author Statement
more info
nucleus IC
Inferred by Curator
more info
nucleus IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
cyclic AMP-responsive element-binding protein 3
basic leucine zipper protein
cyclic AMP response element (CRE)-binding protein/activating transcription factor 1
leucin zipper proitein
small leucine zipper protein
transcription factor LZIP-alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NG_046983.1 RefSeqGene

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006368.5NP_006359.3  cyclic AMP-responsive element-binding protein 3

    See identical proteins and their annotated locations for NP_006359.3

    Status: REVIEWED

    Source sequence(s)
    AF211848, BG701230
    Consensus CDS
    ENSP00000342136.2, ENST00000353704.3
    Conserved Domains (2) summary
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    GlgA; Glycogen synthase [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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