U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ddx1 DEAD box helicase 1 [ Mus musculus (house mouse) ]

Gene ID: 104721, updated on 8-Nov-2022

Summary

Official Symbol
Ddx1provided by MGI
Official Full Name
DEAD box helicase 1provided by MGI
Primary source
MGI:MGI:2144727
See related
Ensembl:ENSMUSG00000037149 AllianceGenome:MGI:2144727
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DBP-RB
Summary
Enables double-stranded RNA binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of myeloid dendritic cell cytokine production. Acts upstream of or within response to exogenous dsRNA and response to virus. Located in cytoplasmic stress granule; cytosol; and mitochondrion. Is expressed in several structures, including 1st branchial arch; cardiovascular system; central nervous system; genitourinary system; and stomach. Orthologous to human DDX1 (DEAD-box helicase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 45.1), CNS E14 (RPKM 31.7) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ddx1 in Genome Data Viewer
Location:
12; 12 A1.1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (13269308..13299175, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (13219307..13249174, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene U8 small nucleolar RNA Neighboring gene ribosomal protein L21, pseudogene 2 Neighboring gene predicted gene, 38686 Neighboring gene predicted gene, 24208 Neighboring gene neuroblastoma amplified sequence Neighboring gene derlin-1-like Neighboring gene predicted gene 6736

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA/RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cleavage body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of tRNA-splicing ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase DDX1
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
DEAD box protein 1
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1
NP_598801.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134040.1NP_598801.1  ATP-dependent RNA helicase DDX1

    See identical proteins and their annotated locations for NP_598801.1

    Status: PROVISIONAL

    Source sequence(s)
    BC010624
    Consensus CDS
    CCDS25819.1
    UniProtKB/Swiss-Prot
    Q3TU41, Q91VR5
    Related
    ENSMUSP00000065987.9, ENSMUST00000071103.10
    Conserved Domains (4) summary
    COG0513
    Location:284624
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00271
    Location:493609
    Helicase_C; Helicase conserved C-terminal domain
    cd12873
    Location:93245
    SPRY_DDX1; SPRY domain associated with DEAD box gene DDX1
    cl21455
    Location:284426
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    13269308..13299175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)