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BAIAP2 BAR/IMD domain containing adaptor protein 2 [ Homo sapiens (human) ]

Gene ID: 10458, updated on 5-Sep-2021

Summary

Official Symbol
BAIAP2provided by HGNC
Official Full Name
BAR/IMD domain containing adaptor protein 2provided by HGNC
Primary source
HGNC:HGNC:947
See related
Ensembl:ENSG00000175866 MIM:605475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAP2; WAML; FLAF3; IRSP53
Summary
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Expression
Broad expression in brain (RPKM 10.7), skin (RPKM 9.8) and 23 other tissues See more
Orthologs
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Genomic context

See BAIAP2 in Genome Data Viewer
Location:
17q25.3
Exon count:
26
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81035131..81117434)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79008951..79091234)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100129503 Neighboring gene BAIAP2 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 8367 Neighboring gene uncharacterized LOC107987250 Neighboring gene Sharpr-MPRA regulatory region 11647 Neighboring gene apoptosis associated tyrosine kinase Neighboring gene microRNA 657

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
BAIAP2 is related to emotional modulation of human memory strength.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 VLP production/release from Jurkat T lymphocytes requires an intact RAC1-WASF2-BAIAP2-ARP3 pathway as demonstrated by siRNA knockdown experiments PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Downregulation of the Wave2 signaling complex (Tiam-1, Abl, Rac, IRSp53, Wave2, and Arp3) with siRNA reduces HIV-1 Env-mediated cell-cell fusion and virus-cell fusion PubMed
Pr55(Gag) gag HIV-1 Gag is required by RAC1-WASF2-BAIAP2-ARP3 pathway for HIV VLP production/release from Jurkat T lymphocytes PubMed
gag HIV-1 Gag intracellular localization is modulated by WASF2 and BAIAP2 as demonstrated by double siRNA knockdowns of these cellular proteins (in Jurkat T cells) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
enables cadherin binding involved in cell-cell adhesion HDA PubMed 
enables cytoskeletal anchor activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables proline-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein C-terminus binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coregulator binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin crosslink formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in axonogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to L-glutamate IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in modification of synaptic structure, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin cytoskeleton reorganization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to synapse IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of modification of postsynaptic actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in adherens junction HDA PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection branch point IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection terminus IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density, intracellular component IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
brain-specific angiogenesis inhibitor 1-associated protein 2
Names
BAI1 associated protein 2
IRS-58
IRSp53/58
WASP and MIM like
fas ligand-associated factor 3
insulin receptor substrate of 53 kDa
insulin receptor substrate p53/p58
insulin receptor substrate protein of 53 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029486.2 RefSeqGene

    Range
    5005..87288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144888.2NP_001138360.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001138360.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) shares identical sequence with variants 1, 2 and 3, but diverges after amino acid 511 resulting in a distinct 23 amino acid sequence at the C-terminus. This transcript variant encodes isoform 4 and is alternatively referred to as variant M.
    Source sequence(s)
    AC115099, BC002495, CB153324
    Consensus CDS
    CCDS45806.1
    UniProtKB/Swiss-Prot
    Q9UQB8
    Related
    ENSP00000401022.2, ENST00000428708.7
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  2. NM_001385127.1NP_001372056.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  3. NM_001385128.1NP_001372057.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  4. NM_001385129.1NP_001372058.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:410468
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  5. NM_001385130.1NP_001372059.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:410468
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  6. NM_001385131.1NP_001372060.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  7. NM_001385132.1NP_001372061.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:410468
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  8. NM_001385133.1NP_001372062.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:411469
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  9. NM_001385134.1NP_001372063.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:410468
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  10. NM_001385135.1NP_001372064.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:411469
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  11. NM_001385136.1NP_001372065.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Related
    ENSP00000461144.1, ENST00000575245.5
    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:410468
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  12. NM_001385137.1NP_001372066.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5261
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:403461
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  13. NM_001385138.1NP_001372067.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  14. NM_001385139.1NP_001372068.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  15. NM_001385140.1NP_001372069.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  16. NM_001385141.1NP_001372070.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  17. NM_001385144.1NP_001372073.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5234
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:375433
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  18. NM_001385145.1NP_001372074.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 19

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variant 22, encodes isoform 19.
    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  19. NM_001385146.1NP_001372075.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 19

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variant 21, encodes isoform 19.
    Source sequence(s)
    AC115099, AC127496
    Related
    ENSP00000458964.1, ENST00000575712.5
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  20. NM_001385147.1NP_001372076.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC115099
    Conserved Domains (2) summary
    cd11915
    Location:319377
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1178
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  21. NM_001385148.1NP_001372077.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variant 25, encodes isoform 21.
    Source sequence(s)
    AC115099, AC127496
    Conserved Domains (2) summary
    cd11915
    Location:319377
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1178
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  22. NM_001385149.1NP_001372078.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variant 24, encodes isoform 21.
    Source sequence(s)
    AC115099
    Conserved Domains (2) summary
    cd11915
    Location:319377
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1178
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  23. NM_001385150.1NP_001372079.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC115099
    Conserved Domains (2) summary
    cd11915
    Location:299357
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  24. NM_001385151.1NP_001372080.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC115099
    Conserved Domains (2) summary
    cd11915
    Location:300358
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  25. NM_001385152.1NP_001372081.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 24

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variant 29, encodes isoform 24.
    Source sequence(s)
    AC115099
    Conserved Domains (2) summary
    cd11915
    Location:299357
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  26. NM_001385153.1NP_001372082.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 24

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variant 28, encodes isoform 24.
    Source sequence(s)
    AC115099
    Conserved Domains (2) summary
    cd11915
    Location:299357
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  27. NM_001385154.1NP_001372083.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 25

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 31 and 32, encodes isoform 25.
    Source sequence(s)
    AC115099
    Conserved Domains (2) summary
    cd11915
    Location:299357
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  28. NM_001385155.1NP_001372084.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 25

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variants 30 and 32, encodes isoform 25.
    Source sequence(s)
    AC115099
    Conserved Domains (2) summary
    cd11915
    Location:299357
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  29. NM_001385156.1NP_001372085.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 25

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 30 and 31, encodes isoform 25.
    Source sequence(s)
    AC115099
    Conserved Domains (2) summary
    cd11915
    Location:299357
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  30. NM_001385157.1NP_001372086.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC115099
    Conserved Domains (1) summary
    cd11915
    Location:134192
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  31. NM_001385158.1NP_001372087.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (34), as well as variant 35, encodes isoform 27.
    Source sequence(s)
    AC115099
    Conserved Domains (1) summary
    cd11915
    Location:134192
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  32. NM_001385159.1NP_001372088.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (35), as well as variant 34, encodes isoform 27.
    Source sequence(s)
    AC115099
    Conserved Domains (1) summary
    cd11915
    Location:134192
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  33. NM_006340.3NP_006331.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 3

    See identical proteins and their annotated locations for NP_006331.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) shares identical sequence with variants 1, 2 and 4, but diverges after amino acid 511 resulting in a distinct 9 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as BAP2-beta or variant T. Variants 3 and 6 both encode the same isoform (3).
    Source sequence(s)
    AB015020, AC115099, BC002495, CB153324
    Consensus CDS
    CCDS11776.1
    UniProtKB/Swiss-Prot
    Q9UQB8
    Related
    ENSP00000413069.3, ENST00000435091.7
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  34. NM_017450.3NP_059344.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_059344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) shares identical sequence with variants 2, 3 and 4, but diverges after amino acid 511 resulting in a distinct 10 amino acid sequence at the C-terminus. This transcript variant encodes isoform 1 and is alternatively referred to as BAP2-alpha, short form, or variant S.
    Source sequence(s)
    AC115099, BC002495, CB153324
    Consensus CDS
    CCDS11777.1
    UniProtKB/Swiss-Prot
    Q9UQB8
    Related
    ENSP00000315685.7, ENST00000321280.11
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  35. NM_017451.3NP_059345.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_059345.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) shares identical sequence with variants 1, 3 and 4, but diverges after amino acid 511 resulting in a distinct 41 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as the long form or variant L. Variants 2 and 5 both encode the same isoform (2).
    Source sequence(s)
    AC115099, BC002495, CB153324
    Consensus CDS
    CCDS11775.1
    UniProtKB/Swiss-Prot
    Q9UQB8
    Related
    ENSP00000316338.6, ENST00000321300.10
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

RNA

  1. NR_169574.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
  2. NR_169575.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
  3. NR_169576.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
  4. NR_169577.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
  5. NR_169578.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
  6. NR_169579.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC115099, AC127496
  7. NR_169580.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC115099

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81035131..81117434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450534.1XP_024306302.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X10

    Conserved Domains (2) summary
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:95237
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_011524194.1XP_011522496.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1

    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:411469
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  3. XM_011524193.1XP_011522495.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X5

    See identical proteins and their annotated locations for XP_011522495.1

    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:411469
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  4. XM_017024017.1XP_016879506.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X8

  5. XM_017024018.1XP_016879507.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X11

    Conserved Domains (2) summary
    cd11915
    Location:300358
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  6. XM_024450535.1XP_024306303.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X11

    Conserved Domains (2) summary
    cd11915
    Location:300358
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  7. XM_017024019.1XP_016879508.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

    Conserved Domains (1) summary
    cd11915
    Location:135193
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  8. XM_011524195.1XP_011522497.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

    See identical proteins and their annotated locations for XP_011522497.1

    Conserved Domains (1) summary
    cd11915
    Location:135193
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  9. XM_011524196.1XP_011522498.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

    See identical proteins and their annotated locations for XP_011522498.1

    Conserved Domains (1) summary
    cd11915
    Location:135193
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
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