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BAIAP2 BAI1 associated protein 2 [ Homo sapiens (human) ]

Gene ID: 10458, updated on 12-Aug-2018

Summary

Official Symbol
BAIAP2provided by HGNC
Official Full Name
BAI1 associated protein 2provided by HGNC
Primary source
HGNC:HGNC:947
See related
Ensembl:ENSG00000175866 MIM:605475; Vega:OTTHUMG00000177698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAP2; FLAF3; IRSP53
Summary
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Expression
Broad expression in brain (RPKM 10.7), skin (RPKM 9.8) and 23 other tissues See more
Orthologs

Genomic context

See BAIAP2 in Genome Data Viewer
Location:
17q25.3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (81035131..81117432)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79008944..79091232)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100129503 Neighboring gene BAIAP2 divergent transcript Neighboring gene uncharacterized LOC107987250 Neighboring gene apoptosis associated tyrosine kinase Neighboring gene microRNA 3065 Neighboring gene microRNA 657 Neighboring gene microRNA 338

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 VLP production/release from Jurkat T lymphocytes requires an intact RAC1-WASF2-BAIAP2-ARP3 pathway as demonstrated by siRNA knockdown experiments PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Downregulation of the Wave2 signaling complex (Tiam-1, Abl, Rac, IRSp53, Wave2, and Arp3) with siRNA reduces HIV-1 Env-mediated cell-cell fusion and virus-cell fusion PubMed
Pr55(Gag) gag HIV-1 Gag is required by RAC1-WASF2-BAIAP2-ARP3 pathway for HIV VLP production/release from Jurkat T lymphocytes PubMed
gag HIV-1 Gag intracellular localization is modulated by WASF2 and BAIAP2 as demonstrated by double siRNA knockdowns of these cellular proteins (in Jurkat T cells) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding involved in cell-cell adhesion HDA PubMed 
cytoskeletal adaptor activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proline-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
transcription cofactor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin crosslink formation ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
axonogenesis TAS
Traceable Author Statement
more info
PubMed 
brain development IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to L-glutamate IEA
Inferred from Electronic Annotation
more info
 
cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
dendrite development IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
modification of synaptic structure, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
plasma membrane organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin cytoskeleton reorganization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
protein localization to synapse IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of modification of postsynaptic actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction HDA PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
dendritic spine cytoplasm IEA
Inferred from Electronic Annotation
more info
 
excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
filopodium IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
neuron projection branch point IEA
Inferred from Electronic Annotation
more info
 
neuron projection terminus IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density, intracellular component IEA
Inferred from Electronic Annotation
more info
 
presynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
ruffle IEA
Inferred from Electronic Annotation
more info
 
secretory granule IEA
Inferred from Electronic Annotation
more info
 
synaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
brain-specific angiogenesis inhibitor 1-associated protein 2
Names
IRS-58
IRSp53/58
fas ligand-associated factor 3
insulin receptor substrate of 53 kDa
insulin receptor substrate p53/p58
insulin receptor substrate protein of 53 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029486.1 RefSeqGene

    Range
    5001..87286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144888.1NP_001138360.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001138360.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) shares identical sequence with variants 1, 2 and 3, but diverges after amino acid 511 resulting in a distinct 23 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as variant M.
    Source sequence(s)
    AC115099, BC002495, CB153324
    Consensus CDS
    CCDS45806.1
    UniProtKB/Swiss-Prot
    Q9UQB8
    Related
    ENSP00000401022.2, OTTHUMP00000257470, ENST00000428708.6, OTTHUMT00000438549
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  2. NM_006340.2NP_006331.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 3

    See identical proteins and their annotated locations for NP_006331.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) shares identical sequence with variants 1, 2 and 4, but diverges after amino acid 511 resulting in a distinct 9 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as BAP2-beta or variant T.
    Source sequence(s)
    AB015020, AC115099, BC002495, CB153324
    Consensus CDS
    CCDS11776.1
    UniProtKB/Swiss-Prot
    Q9UQB8
    Related
    ENSP00000413069.3, OTTHUMP00000257536, ENST00000435091.7, OTTHUMT00000438552
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  3. NM_017450.2NP_059344.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_059344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) shares identical sequence with variants 2, 3 and 4, but diverges after amino acid 511 resulting in a distinct 10 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as BAP2-alpha, short form, or variant S.
    Source sequence(s)
    AC115099, BC002495, CB153324
    Consensus CDS
    CCDS11777.1
    UniProtKB/Swiss-Prot
    Q9UQB8
    Related
    ENSP00000315685.7, OTTHUMP00000257469, ENST00000321280.11, OTTHUMT00000438547
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  4. NM_017451.2NP_059345.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_059345.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) shares identical sequence with variants 1, 3 and 4, but diverges after amino acid 511 resulting in a distinct 41 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as the long form or variant L.
    Source sequence(s)
    AC115099, BC002495, CB153324
    Consensus CDS
    CCDS11775.1
    UniProtKB/Swiss-Prot
    Q9UQB8
    Related
    ENSP00000316338.6, OTTHUMP00000257471, ENST00000321300.10, OTTHUMT00000438553
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:377435
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    81035131..81117432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450534.1XP_024306302.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X10

    Conserved Domains (2) summary
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:95237
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_006721636.1XP_006721699.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X5

    See identical proteins and their annotated locations for XP_006721699.1

    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:411469
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  3. XM_011524194.1XP_011522496.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1

    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:411469
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  4. XM_005256945.1XP_005257002.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X6

    UniProtKB/TrEMBL
    I3L4C2
    Related
    ENSP00000461144.1, OTTHUMP00000257535, ENST00000575245.5, OTTHUMT00000438551
    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:410468
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  5. XM_005256943.1XP_005257000.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2

    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:410468
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  6. XM_006721637.2XP_006721700.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X7

    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  7. XM_011524193.1XP_011522495.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X5

    See identical proteins and their annotated locations for XP_011522495.1

    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:411469
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  8. XM_006721635.1XP_006721698.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X3

    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:411469
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  9. XM_005256944.1XP_005257001.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X4

    Conserved Domains (2) summary
    cd07646
    Location:5269
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:410468
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  10. XM_005256948.3XP_005257005.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X9

    See identical proteins and their annotated locations for XP_005257005.1

    UniProtKB/Swiss-Prot
    Q9UQB8
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  11. XM_017024017.1XP_016879506.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X8

  12. XM_017024018.1XP_016879507.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X11

    Conserved Domains (2) summary
    cd11915
    Location:300358
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  13. XM_024450535.1XP_024306303.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X11

    Conserved Domains (2) summary
    cd11915
    Location:300358
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  14. XM_017024019.1XP_016879508.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

    Conserved Domains (1) summary
    cd11915
    Location:135193
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  15. XM_011524195.1XP_011522497.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

    See identical proteins and their annotated locations for XP_011522497.1

    Conserved Domains (1) summary
    cd11915
    Location:135193
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  16. XM_011524196.1XP_011522498.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

    See identical proteins and their annotated locations for XP_011522498.1

    Conserved Domains (1) summary
    cd11915
    Location:135193
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  17. XM_011524197.1XP_011522499.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X13

    Conserved Domains (1) summary
    cd11915
    Location:134192
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
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