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CPQ carboxypeptidase Q [ Homo sapiens (human) ]

Gene ID: 10404, updated on 5-Jul-2020

Summary

Official Symbol
CPQprovided by HGNC
Official Full Name
carboxypeptidase Qprovided by HGNC
Primary source
HGNC:HGNC:16910
See related
Ensembl:ENSG00000104324 MIM:618754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LDP; PGCP
Summary
This gene encodes a metallopeptidase that belongs to the peptidase M28 family. The encoded protein may catalyze the cleavage of dipeptides with unsubstituted terminals into amino acids. [provided by RefSeq, Jul 2013]
Expression
Broad expression in thyroid (RPKM 83.5), ovary (RPKM 28.7) and 24 other tissues See more
Orthologs

Genomic context

See CPQ in Genome Data Viewer
Location:
8q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (96645242..97143501)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (97657455..98155731)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375653 Neighboring gene RNA, U6 small nuclear 1172, pseudogene Neighboring gene syndecan 2 Neighboring gene uncharacterized LOC101927066 Neighboring gene uncharacterized LOC105375655 Neighboring gene Sharpr-MPRA regulatory region 10694

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of sleep habits and insomnia.
NHGRI GWA Catalog
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metallodipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallodipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
thyroid hormone generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thyroid hormone generation ISS
Inferred from Sequence or Structural Similarity
more info
 
tissue regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
carboxypeptidase Q
Names
Ser-Met dipeptidase
aminopeptidase
blood plasma glutamate carboxypeptidase
lysosomal dipeptidase
NP_057218.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016134.4NP_057218.1  carboxypeptidase Q preproprotein

    See identical proteins and their annotated locations for NP_057218.1

    Status: REVIEWED

    Source sequence(s)
    AA492294, AK315447, DA699663
    Consensus CDS
    CCDS6273.1
    UniProtKB/Swiss-Prot
    Q9Y646
    UniProtKB/TrEMBL
    A0A024R9B8
    Related
    ENSP00000220763.5, ENST00000220763.10
    Conserved Domains (2) summary
    cd03883
    Location:47449
    M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
    cd04815
    Location:130256
    PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    96645242..97143501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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