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Cpq carboxypeptidase Q [ Mus musculus (house mouse) ]

Gene ID: 54381, updated on 30-Apr-2024

Summary

Official Symbol
Cpqprovided by MGI
Official Full Name
carboxypeptidase Qprovided by MGI
Primary source
MGI:MGI:1889205
See related
Ensembl:ENSMUSG00000039007 AllianceGenome:MGI:1889205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hls2; Pgcp; Lal-1; 1190003P12Rik; 2610034C17Rik
Summary
Predicted to enable metallodipeptidase activity and protein homodimerization activity. Predicted to be involved in peptide catabolic process; proteolysis; and thyroid hormone generation. Located in lysosome. Is expressed in genitourinary system. Orthologous to human CPQ (carboxypeptidase Q). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 26.1), subcutaneous fat pad adult (RPKM 15.4) and 25 other tissues See more
Orthologs
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Genomic context

See Cpq in Genome Data Viewer
Location:
15 B3.1; 15 13.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (33083275..33594698)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (33083129..33594552)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53871 Neighboring gene syndecan 2 Neighboring gene STARR-seq mESC enhancer starr_38300 Neighboring gene STARR-seq mESC enhancer starr_38301 Neighboring gene predicted gene, 32764 Neighboring gene STARR-seq mESC enhancer starr_38302 Neighboring gene STARR-seq mESC enhancer starr_38303 Neighboring gene ribosomal protein L7-like 1 pseudogene Neighboring gene RIKEN cDNA 4930592A05 gene Neighboring gene STARR-seq mESC enhancer starr_38305 Neighboring gene predicted gene, 53872 Neighboring gene testis-specific protein, Y-encoded-like 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallodipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallodipeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in thyroid hormone generation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carboxypeptidase Q
Names
hematopoietic lineage switch 2
plasma glutamate carboxypeptidase
NP_061225.2
NP_788262.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018755.2NP_061225.2  carboxypeptidase Q precursor

    See identical proteins and their annotated locations for NP_061225.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK152145, BB472698, CK624628
    Consensus CDS
    CCDS27414.1
    UniProtKB/Swiss-Prot
    O70216, Q3U8N9, Q9WVJ3
    Related
    ENSMUSP00000154400.2, ENSMUST00000228916.2
    Conserved Domains (2) summary
    cd03883
    Location:45447
    M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
    cd04815
    Location:128254
    PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...
  2. NM_176073.4NP_788262.1  carboxypeptidase Q precursor

    See identical proteins and their annotated locations for NP_788262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK135096, BB472698, CK624628
    Consensus CDS
    CCDS27414.1
    UniProtKB/Swiss-Prot
    O70216, Q3U8N9, Q9WVJ3
    Related
    ENSMUSP00000039046.10, ENSMUST00000042167.10
    Conserved Domains (2) summary
    cd03883
    Location:45447
    M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
    cd04815
    Location:128254
    PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    33083275..33594698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)