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PRG3 proteoglycan 3, pro eosinophil major basic protein 2 [ Homo sapiens (human) ]

Gene ID: 10394, updated on 1-Jun-2020

Summary

Official Symbol
PRG3provided by HGNC
Official Full Name
proteoglycan 3, pro eosinophil major basic protein 2provided by HGNC
Primary source
HGNC:HGNC:9363
See related
Ensembl:ENSG00000156575 MIM:606814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MBP2; MBPH
Expression
Restricted expression toward bone marrow (RPKM 15.2) See more
Orthologs

Genomic context

See PRG3 in Genome Data Viewer
Location:
11q12.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (57376769..57381150, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57144242..57148623, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene structure specific recognition protein 1 Neighboring gene purinergic receptor P2X 3 Neighboring gene uncharacterized LOC105369312 Neighboring gene proteoglycan 2, pro eosinophil major basic protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-Tat peptide interferes with polyamine uptake via competition for proteoglycan binding sites rather than a putative downstream transporter in human carcinoma cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126662, MGC141971

General protein information

Preferred Names
proteoglycan 3
Names
eosinophil major basic protein homolog
prepro-MBPH
prepro-major basic protein homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006093.4NP_006084.2  proteoglycan 3 precursor

    See identical proteins and their annotated locations for NP_006084.2

    Status: VALIDATED

    Source sequence(s)
    AF132209, AP000781, AY358930
    Consensus CDS
    CCDS7954.1
    UniProtKB/Swiss-Prot
    Q9Y2Y8
    Related
    ENSP00000287143.2, ENST00000287143.2
    Conserved Domains (1) summary
    cd03598
    Location:110225
    CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    57376769..57381150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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