U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vav1 vav guanine nucleotide exchange factor 1 [ Nannospalax galili (Upper Galilee mountains blind mole rat) ]

Gene ID: 103737178, updated on 11-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
Vav1
Gene description
vav guanine nucleotide exchange factor 1
See related
Ensembl:ENSNGAG00000018348
Gene type
protein coding
RefSeq status
MODEL
Organism
Nannospalax galili
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Spalacidae; Spalacinae; Nannospalax
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: Un
Exon count:
29
Annotation release Status Assembly Chr Location
102 current S.galili_v1.0 (GCF_000622305.1) Unplaced Scaffold NW_008341457.1 (379792..447257, complement)

NW_008341457.1Genomic Context describing neighboring genes Neighboring gene vomeronasal type-2 receptor 116-like Neighboring gene adhesion G protein-coupled receptor E1 Neighboring gene small nucleolar RNA SNORA4 Neighboring gene SH2 domain containing 3A Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene G protein-coupled receptor 108

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NW_008341457 Unplaced Scaffold Reference S.galili_v1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transcriptome sequencing of the blind subterranean mole rat, Spalax galili: utility and potential for the discovery of novel evolutionary patterns. Malik A, et al. PLoS One, 2011. PMID 21857902, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
proto-oncogene vav

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Nannospalax galili Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference S.galili_v1.0 Primary Assembly

Genomic

  1. NW_008341457.1 Reference S.galili_v1.0 Primary Assembly

    Range
    379792..447257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029565287.1 → XP_029421147.1  proto-oncogene vav isoform X2

    UniProtKB/TrEMBL
    A0A8C6RHF7
    Conserved Domains (6) summary
    cd11976
    Location:660 → 713
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:470 → 532
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:69 → 245
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:259 → 382
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00130
    Location:390 → 438
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl15255
    Location:539 → 641
    SH2; Src homology 2 (SH2) domain

  2. XM_008836894.3 → XP_008835116.1  proto-oncogene vav isoform X1

    UniProtKB/TrEMBL
    A0A8C6RFG1, A0A8C6RHF7
    Related
    ENSNGAP00000018167.1, ENSNGAT00000023810.1
    Conserved Domains (7) summary
    cd10405
    Location:665 → 767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:786 → 839
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596 → 658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00130
    Location:516 → 564
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl00030
    Location:18 → 102
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.