U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vav1 vav 1 oncogene [ Mus musculus (house mouse) ]

Gene ID: 22324, updated on 30-Aug-2022

Summary

Official Symbol
Vav1provided by MGI
Official Full Name
vav 1 oncogeneprovided by MGI
Primary source
MGI:MGI:98923
See related
Ensembl:ENSMUSG00000034116 AllianceGenome:MGI:98923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vav; vav-T
Summary
Enables guanyl-nucleotide exchange factor activity and phosphorylation-dependent protein binding activity. Acts upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of natural killer cell mediated cytotoxicity. Located in cell-cell junction. Is expressed in several structures, including dorsal aorta; extraembryonic component; hemolymphoid system; pancreas; and reproductive system. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 27.9), spleen adult (RPKM 15.9) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Vav1 in Genome Data Viewer
Location:
17 D; 17 29.76 cM
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57586080..57636236)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57279100..57329236)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (57418523..57468659)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 3A pseudogene Neighboring gene predicted gene, 52326 Neighboring gene adhesion G protein-coupled receptor E1 Neighboring gene heat shock protein 8 pseudogene Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (6) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphorylation-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within integrin-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within reactive oxygen species metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
proto-oncogene vav
Names
p95vav
vav oncogene

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163815.1NP_001157287.1  proto-oncogene vav isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK151214, AK152555, BY496946, CT010434
    Consensus CDS
    CCDS50158.1
    UniProtKB/TrEMBL
    A0A8C6HRA0, E9PXI0, Q3U9E2, Q3UAV5
    Related
    ENSMUSP00000126694.3, ENSMUST00000169220.9
    Conserved Domains (7) summary
    cd10405
    Location:641743
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:762815
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:572634
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:171347
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:361484
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00130
    Location:492543
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl00030
    Location:2978
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
  2. NM_001163816.1NP_001157288.1  proto-oncogene vav isoform 3

    See identical proteins and their annotated locations for NP_001157288.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    BY139350, BY496946, CT010321, CT010434
    Consensus CDS
    CCDS50159.1
    UniProtKB/TrEMBL
    A0A8C6HRC4, Q8VDU4
    Related
    ENSMUSP00000108491.5, ENSMUST00000112870.5
    Conserved Domains (7) summary
    cd11976
    Location:747800
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385508
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00130
    Location:516567
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl00030
    Location:18102
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl15255
    Location:665728
    SH2; Src homology 2 (SH2) domain
  3. NM_011691.4NP_035821.3  proto-oncogene vav isoform 1

    See identical proteins and their annotated locations for NP_035821.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK152555, BY139350, BY496946, CT010434
    Consensus CDS
    CCDS28931.1
    UniProtKB/Swiss-Prot
    P27870, Q8BTV7
    UniProtKB/TrEMBL
    A0A6P5R965, A0A8C6HPQ3, Q3U9E2
    Related
    ENSMUSP00000005889.10, ENSMUST00000005889.16
    Conserved Domains (7) summary
    cd10405
    Location:665767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:786839
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385508
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00130
    Location:516567
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl00030
    Location:18102
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57586080..57636236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_385313.4 RNA Sequence