Format

Send to:

Choose Destination

NPM3 nucleophosmin/nucleoplasmin 3 [ Homo sapiens (human) ]

Gene ID: 10360, updated on 1-Aug-2020

Summary

Official Symbol
NPM3provided by HGNC
Official Full Name
nucleophosmin/nucleoplasmin 3provided by HGNC
Primary source
HGNC:HGNC:7931
See related
Ensembl:ENSG00000107833 MIM:606456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PORMIN; TMEM123
Summary
The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in testis (RPKM 11.1), appendix (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See NPM3 in Genome Data Viewer
Location:
10q24.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (101781325..101783413, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103541082..103543170, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378457 Neighboring gene FGF8 5' regulatory region Neighboring gene fibroblast growth factor 8 Neighboring gene VISTA enhancer hs513 Neighboring gene O-GlcNAcase Neighboring gene KCNIP2 antisense RNA 1 Neighboring gene potassium voltage-gated channel interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with nucleophosmin/nucleoplasmin 3 (NPM3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
rRNA transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nucleoplasmin-3
Names
nucleophosmin/nucleoplasmin family, member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006993.2NP_008924.1  nucleoplasmin-3

    See identical proteins and their annotated locations for NP_008924.1

    Status: REVIEWED

    Source sequence(s)
    BC054868, BM739536
    Consensus CDS
    CCDS7519.1
    UniProtKB/Swiss-Prot
    O75607
    Related
    ENSP00000359128.5, ENST00000370110.5
    Conserved Domains (1) summary
    pfam03066
    Location:38137
    Nucleoplasmin; Nucleoplasmin/nucleophosmin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    101781325..101783413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center