Epop elongin BC and polycomb repressive complex 2 associated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Epopprovided by MGI
Official Full Name: elongin BC and polycomb repressive complex 2 associated proteinprovided by MGI
Primary source: MGI:MGI:2143991
See related: Ensembl:ENSMUSG00000043439 AllianceGenome:MGI:2143991
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E13; esPRC2p48; E130012A19Rik
Summary: Enables chromatin binding activity. Involved in regulation of transcription by RNA polymerase II; stem cell differentiation; and transcription elongation-coupled chromatin remodeling. Acts upstream of or within neuron fate commitment. Part of ESC/E(Z) complex and elongin complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human EPOP (elongin BC and polycomb repressive complex 2 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 11 D; 11 61.03 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (97518213..97520542, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (97627387..97629716, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations.
Title: Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations.
Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.
Title: Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.
PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.
Title: PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.
EPOP (E130012A19Rik) interacts with elongin B, elongin C, and USP7 to modulate the chromatin landscape.
Title: EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.
EPOP (E130012A19Rik) functionally links elongin B, elongin C, and polycomb in pluripotent stem cells.
Title: EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells.
Results demonstrated that E130012A19Rik (E13), is a protein-coding gene implicated in regulating the commitment towards the different neuronal subtypes and glia cells.
Title: Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation.
these studies identify JARID2, MTF2, and esPRC2p48 as important regulatory subunits of PRC2 in ES cells and reveal critical functions of these subunits.
Title: PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129966 (e-PCR)
- UniSTS:213254

RH124828 (e-PCR)
- UniSTS:161650

AI413509 (e-PCR)
- UniSTS:160148

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in neuron fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron fate commitment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of elongin complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: elongin BC and Polycomb repressive complex 2-associated protein

Names: ES cell-specific PRC2 subunit p48; elongin and polycomb associated protein; embryonic stem cell-specific PRC2 subunit p48; uncharacterized protein C17orf96 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.