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Epop elongin BC and polycomb repressive complex 2 associated protein [ Mus musculus (house mouse) ]

Gene ID: 103551, updated on 26-Sep-2022

Summary

Official Symbol
Epopprovided by MGI
Official Full Name
elongin BC and polycomb repressive complex 2 associated proteinprovided by MGI
Primary source
MGI:MGI:2143991
See related
Ensembl:ENSMUSG00000043439 AllianceGenome:MGI:2143991
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E13; esPRC2p48; E130012A19Rik
Summary
Enables chromatin binding activity. Involved in histone H2B conserved C-terminal lysine deubiquitination; regulation of transcription by RNA polymerase II; and stem cell differentiation. Acts upstream of or within neuron fate commitment. Part of ESC/E(Z) complex and elongin complex. Orthologous to human EPOP (elongin BC and polycomb repressive complex 2 associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Epop in Genome Data Viewer
Location:
11; 11 D
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97518213..97520542, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97627387..97629716, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SRC kinase signaling inhibitor 1 Neighboring gene RIKEN cDNA 2410003L11 gene Neighboring gene predicted gene, 38962 Neighboring gene predicted gene 11613 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 Neighboring gene microRNA 6927

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
part_of elongin complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
elongin BC and Polycomb repressive complex 2-associated protein
Names
ES cell-specific PRC2 subunit p48
elongin and polycomb associated protein
embryonic stem cell-specific PRC2 subunit p48
uncharacterized protein C17orf96 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175332.3NP_780541.2  elongin BC and Polycomb repressive complex 2-associated protein

    See identical proteins and their annotated locations for NP_780541.2

    Status: PROVISIONAL

    Source sequence(s)
    BC055770
    Consensus CDS
    CCDS25322.1
    UniProtKB/Swiss-Prot
    Q7TNS8, Q99JK6
    Related
    ENSMUSP00000051211.5, ENSMUST00000052281.6
    Conserved Domains (1) summary
    pfam15223
    Location:295357
    DUF4584; Domain of unknown function (DUF4584)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97518213..97520542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)