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EPOP elongin BC and polycomb repressive complex 2 associated protein [ Homo sapiens (human) ]

Gene ID: 100170841, updated on 23-Nov-2023

Summary

Official Symbol
EPOPprovided by HGNC
Official Full Name
elongin BC and polycomb repressive complex 2 associated proteinprovided by HGNC
Primary source
HGNC:HGNC:34493
See related
Ensembl:ENSG00000273604 MIM:617795; AllianceGenome:HGNC:34493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRR28; C17orf96
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including histone H2B conserved C-terminal lysine deubiquitination; neuron fate commitment; and stem cell differentiation. Predicted to be located in chromosome. Predicted to colocalize with ESC/E(Z) complex and elongin complex. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See EPOP in Genome Data Viewer
Location:
17q12
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38671703..38674957, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39534773..39538027, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36827956..36831210, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SRC kinase signaling inhibitor 1 Neighboring gene uncharacterized LOC105371761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36720624-36721176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36721177-36721728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36722271-36722779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36734639-36735366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36735367-36736094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36748159-36748740 Neighboring gene uncharacterized LOC124903992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36749033-36749534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36749535-36750034 Neighboring gene Sharpr-MPRA regulatory region 8854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36763065-36763666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36763667-36764267 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36765411-36766081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36775868-36776378 Neighboring gene Sharpr-MPRA regulatory region 2012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36814959-36815458 Neighboring gene Sharpr-MPRA regulatory region 11404 Neighboring gene Sharpr-MPRA regulatory region 8107 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36829618-36830453 Neighboring gene Sharpr-MPRA regulatory region 4536 Neighboring gene uncharacterized LOC105371763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36858367-36858898 Neighboring gene uncharacterized LOC124903993 Neighboring gene microRNA 4734 Neighboring gene MLLT6, PHD finger containing

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-containing complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in neuron fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transcription elongation-coupled chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
part_of elongin complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
elongin BC and Polycomb repressive complex 2-associated protein
Names
proline rich 28
proline-rich protein 28
uncharacterized protein C17orf96

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130677.2NP_001124149.1  elongin BC and Polycomb repressive complex 2-associated protein

    See identical proteins and their annotated locations for NP_001124149.1

    Status: VALIDATED

    Source sequence(s)
    AC006449
    Consensus CDS
    CCDS45661.1
    UniProtKB/Swiss-Prot
    A6NHQ4
    Related
    ENSP00000484710.1, ENST00000621654.2
    Conserved Domains (1) summary
    pfam15223
    Location:305371
    DUF4584; Domain of unknown function (DUF4584)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    38671703..38674957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2707022..2710276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    39534773..39538027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)