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Pan2 PAN2 poly(A) specific ribonuclease subunit [ Mus musculus (house mouse) ]

Gene ID: 103135, updated on 12-May-2024

Summary

Official Symbol
Pan2provided by MGI
Official Full Name
PAN2 poly(A) specific ribonuclease subunitprovided by MGI
Primary source
MGI:MGI:1918984
See related
Ensembl:ENSMUSG00000005682 AllianceGenome:MGI:1918984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Usp52; mKIAA0710; 1200014O24Rik
Summary
Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process, exonucleolytic. Located in P-body. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; primary oocyte; and secondary oocyte. Orthologous to human PAN2 (poly(A) specific ribonuclease subunit PAN2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 19.4), limb E14.5 (RPKM 15.5) and 28 other tissues See more
Orthologs
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Genomic context

See Pan2 in Genome Data Viewer
Location:
10 D3; 10 76.51 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128135106..128157227)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128303333..128321358)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5199 Neighboring gene apolipoprotein F Neighboring gene signal transducer and activator of transcription 2 Neighboring gene STARR-seq mESC enhancer starr_28274 Neighboring gene STARR-positive B cell enhancer ABC_E194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127740631-127740818 Neighboring gene interleukin 23, alpha subunit p19 Neighboring gene predicted gene, 23241 Neighboring gene canopy FGF signaling regulator 2 Neighboring gene STARR-positive B cell enhancer ABC_E9813 Neighboring gene STARR-positive B cell enhancer ABC_E1134 Neighboring gene STARR-positive B cell enhancer ABC_E11467 Neighboring gene citrate synthase Neighboring gene predicted gene, 23182

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
part_of PAN complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of PAN complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PAN2-PAN3 deadenylation complex catalytic subunit Pan2
Names
AN2 polyA specific ribonuclease subunit homolog
PAB-dependent poly(A)-specific ribonuclease subunit 2
PAB-dependent poly(A)-specific ribonuclease subunit PAN2
PAB1P-dependent poly(A)-nuclease
PAN deadenylation complex catalytic subunit 2
PAN2 polyA specific ribonuclease subunit homolog
inactive ubiquitin carboxyl-terminal hydrolase 52
poly(A)-nuclease deadenylation complex subunit 2
ubiquitin specific peptidase 52
ubiquitin specific protease 52
NP_001239255.1
NP_001239256.1
NP_001345751.1
NP_598753.1
XP_006513048.1
XP_006513049.1
XP_006513050.1
XP_006513051.1
XP_006513052.1
XP_006513053.1
XP_036011343.1
XP_036011344.1
XP_036011345.1
XP_036011346.1
XP_036011347.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252326.1NP_001239255.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 2

    See identical proteins and their annotated locations for NP_001239255.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC135859, AK004773, BC079841, CF170307
    Consensus CDS
    CCDS88107.1
    UniProtKB/Swiss-Prot
    Q8BGF7
    Related
    ENSMUSP00000151216.2, ENSMUST00000218315.2
    Conserved Domains (4) summary
    cd06143
    Location:9651138
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:501911
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam13423
    Location:516888
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl02567
    Location:75357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001252327.1NP_001239256.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC135859, AK004773, AK157800, BG086688
    Consensus CDS
    CCDS88108.1
    UniProtKB/Swiss-Prot
    Q8BGF7
    Related
    ENSMUSP00000151874.2, ENSMUST00000219721.2
    Conserved Domains (4) summary
    cd06143
    Location:9471120
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:483893
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam13423
    Location:498870
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl02567
    Location:75339
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001358822.1NP_001345751.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC135859, AK004773, AK047887, CN527165, CX566326
    Related
    ENSMUST00000218496.2
    Conserved Domains (3) summary
    cd06143
    Location:8361009
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:362782
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl25539
    Location:21218
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_133992.3NP_598753.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 1

    See identical proteins and their annotated locations for NP_598753.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AC135859, AK004773, AK047887
    Consensus CDS
    CCDS24271.1
    UniProtKB/Swiss-Prot
    Q3TZK5, Q68FH6, Q6ZQ63, Q8BGF7
    Related
    ENSMUSP00000005825.7, ENSMUST00000005825.8
    Conserved Domains (4) summary
    cd06143
    Location:9741147
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:501920
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam13423
    Location:516897
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl02567
    Location:75357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128135106..128157227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155450.1XP_036011343.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X1

    Conserved Domains (3) summary
    cd06143
    Location:9791152
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516902
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006512985.4XP_006513048.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X1

    Conserved Domains (3) summary
    cd06143
    Location:9791152
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516902
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_006512989.3XP_006513052.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X6

    Conserved Domains (3) summary
    pfam13423
    Location:516902
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl10012
    Location:9791092
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl29593
    Location:75357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_006512988.4XP_006513051.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X4

    Conserved Domains (3) summary
    cd06143
    Location:9701143
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516893
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_036155453.1XP_036011346.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X8

    Conserved Domains (3) summary
    pfam13423
    Location:516893
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl10012
    Location:9701083
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl29593
    Location:75357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_006512987.4XP_006513050.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X3

    Conserved Domains (3) summary
    cd06143
    Location:9751148
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516898
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_036155452.1XP_036011345.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X7

    Conserved Domains (3) summary
    pfam13423
    Location:516898
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl10012
    Location:9751088
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl29593
    Location:75357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_036155451.1XP_036011344.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X5

    Conserved Domains (3) summary
    cd06143
    Location:9661139
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516889
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_006512986.4XP_006513049.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X2

    Conserved Domains (3) summary
    cd06143
    Location:9781151
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516901
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. XM_006512990.4XP_006513053.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X9

    Conserved Domains (3) summary
    cd06143
    Location:8401013
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:377763
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:21218
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_036155454.1XP_036011347.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X10

    Conserved Domains (3) summary
    cd06143
    Location:8351008
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:377758
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:21218
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_380330.4 RNA Sequence

  2. XR_380328.3 RNA Sequence

  3. XR_001779394.3 RNA Sequence

  4. XR_380329.4 RNA Sequence

  5. XR_003948564.2 RNA Sequence

  6. XR_004936004.1 RNA Sequence

  7. XR_003948567.2 RNA Sequence

  8. XR_004936003.1 RNA Sequence

  9. XR_004936005.1 RNA Sequence