Format

Send to:

Choose Destination

PAN2 poly(A) specific ribonuclease subunit PAN2 [ Homo sapiens (human) ]

Gene ID: 9924, updated on 26-Sep-2020

Summary

Official Symbol
PAN2provided by HGNC
Official Full Name
poly(A) specific ribonuclease subunit PAN2provided by HGNC
Primary source
HGNC:HGNC:20074
See related
Ensembl:ENSG00000135473 MIM:617447
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
USP52
Summary
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in testis (RPKM 19.6), thyroid (RPKM 18.6) and 25 other tissues See more
Orthologs

Genomic context

See PAN2 in Genome Data Viewer
Location:
12q13.3
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56316223..56334000, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56710007..56727837, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene citrate synthase Neighboring gene uncharacterized LOC112268098 Neighboring gene canopy FGF signaling regulator 2 Neighboring gene interleukin 23 subunit alpha Neighboring gene signal transducer and activator of transcription 2 Neighboring gene RNA, U7 small nuclear 40 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
GeneReviews: Not available
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39360, KIAA0710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
poly(A)-specific ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
poly(A)-specific ribonuclease activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT thiol-dependent ubiquitin-specific protease activity IKR
Inferred from Key Residues
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA poly(A) tail shortening TAS
Traceable Author Statement
more info
 
positive regulation of cytoplasmic mRNA processing body assembly IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PAN complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PAN complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Names
PAB-dependent poly(A)-specific ribonuclease subunit 2
PAB-dependent poly(A)-specific ribonuclease subunit PAN2
PAB1P-dependent poly(A)-nuclease
PAB1P-dependent poly(A)-specific ribonuclease
PABP-dependent poly(A) nuclease 2
PAN deadenylation complex catalytic subunit 2
PAN deadenylation complex subunit 2
PAN2 poly(A) specific ribonuclease subunit homolog
inactive ubiquitin carboxyl-terminal hydrolase 52
poly(A)-nuclease deadenylation complex subunit 2
ubiquitin specific peptidase 52
ubiquitin specific protease 52
NP_001120932.2
NP_001159751.2
NP_055686.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127460.3NP_001120932.2  PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC073896
    Consensus CDS
    CCDS44922.1
    Related
    ENSP00000401721.2, ENST00000425394.7
    Conserved Domains (3) summary
    cd06143
    Location:9751148
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:517898
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:204357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001166279.2NP_001159751.2  PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC025574, AC073896
    Consensus CDS
    CCDS53802.1
    Related
    ENSP00000257931.5, ENST00000257931.9
    Conserved Domains (3) summary
    cd06143
    Location:9741147
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:517897
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:204357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_014871.5NP_055686.4  PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC025574, AC073896
    Consensus CDS
    CCDS8915.1
    Related
    ENSP00000388231.3, ENST00000440411.7
    Conserved Domains (3) summary
    cd06143
    Location:9711144
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:517894
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:204357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56316223..56334000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center