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RAMP2 receptor activity modifying protein 2 [ Homo sapiens (human) ]

Gene ID: 10266, updated on 18-Aug-2020

Summary

Official Symbol
RAMP2provided by HGNC
Official Full Name
receptor activity modifying protein 2provided by HGNC
Primary source
HGNC:HGNC:9844
See related
Ensembl:ENSG00000131477 MIM:605154
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 58.9), fat (RPKM 57.7) and 22 other tissues See more
Orthologs

Genomic context

See RAMP2 in Genome Data Viewer
Location:
17q21.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (42761227..42763041)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40913145..40915063)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit Neighboring gene ribosomal protein L34 pseudogene 30 Neighboring gene RAMP2 antisense RNA 1 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 15 Neighboring gene vacuolar protein sorting 25 homolog Neighboring gene WNK lysine deficient protein kinase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adrenomedullin binding IPI
Inferred from Physical Interaction
more info
PubMed 
adrenomedullin receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to amylin receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coreceptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
adherens junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
adrenomedullin receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
amylin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
basement membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
bicellular tight junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IDA
Inferred from Direct Assay
more info
PubMed 
receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
vascular smooth muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
adrenomedullin receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
amylin receptor complex 2 IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated pit TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
lysosome TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
receptor activity-modifying protein 2
Names
CRLR activity-modifying protein 2
calcitonin receptor-like receptor activity modifying protein 2
receptor (G protein-coupled) activity modifying protein 2
receptor (calcitonin) activity modifying protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005854.3NP_005845.2  receptor activity-modifying protein 2 precursor

    See identical proteins and their annotated locations for NP_005845.2

    Status: REVIEWED

    Source sequence(s)
    AL548945, BC027975
    Consensus CDS
    CCDS11437.1
    UniProtKB/Swiss-Prot
    O60895
    UniProtKB/TrEMBL
    A0A024R1Z2
    Related
    ENSP00000253796.3, ENST00000253796.10
    Conserved Domains (1) summary
    pfam04901
    Location:65172
    RAMP; Receptor activity modifying family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    42761227..42763041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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