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Ramp2 receptor (calcitonin) activity modifying protein 2 [ Mus musculus (house mouse) ]

Gene ID: 54409, updated on 26-Sep-2022

Summary

Official Symbol
Ramp2provided by MGI
Official Full Name
receptor (calcitonin) activity modifying protein 2provided by MGI
Primary source
MGI:MGI:1859650
See related
Ensembl:ENSMUSG00000001240 AllianceGenome:MGI:1859650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables coreceptor activity. Involved in several processes, including cell-cell junction assembly; circulatory system development; and negative regulation of endothelial cell apoptotic process. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of adrenomedullin receptor complex and amylin receptor complex 2. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Is expressed in several structures, including cardiovascular system; forelimb bud; gut; liver; and prostate gland lobe. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RAMP2 (receptor activity modifying protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 313.3), subcutaneous fat pad adult (RPKM 94.5) and 14 other tissues See more
Orthologs
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Genomic context

See Ramp2 in Genome Data Viewer
Location:
11 D; 11 64.47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101137160..101139076)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101246334..101248250)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene contactin associated protein-like 1 Neighboring gene chemokine (C-C motif) receptor 10 Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit Neighboring gene vacuolar protein sorting 25 Neighboring gene WNK lysine deficient protein kinase 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adrenomedullin binding ISO
Inferred from Sequence Orthology
more info
 
enables adrenomedullin receptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to amylin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables coreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adherens junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adherens junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in adrenomedullin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in amylin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in basement membrane assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular associated smooth muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of adrenomedullin receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of amylin receptor complex 2 ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor activity-modifying protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019444.2NP_062317.1  receptor activity-modifying protein 2 precursor

    See identical proteins and their annotated locations for NP_062317.1

    Status: VALIDATED

    Source sequence(s)
    AK003810, BC051201, BY312723
    Consensus CDS
    CCDS25457.1
    UniProtKB/Swiss-Prot
    Q6IS25, Q9WUP0
    Related
    ENSMUSP00000122072.2, ENSMUST00000129680.8
    Conserved Domains (1) summary
    pfam04901
    Location:83186
    RAMP; Receptor activity modifying family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101137160..101139076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)