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IGSF6 immunoglobulin superfamily member 6 [ Homo sapiens (human) ]

Gene ID: 10261, updated on 3-Oct-2020

Summary

Official Symbol
IGSF6provided by HGNC
Official Full Name
immunoglobulin superfamily member 6provided by HGNC
Primary source
HGNC:HGNC:5953
See related
Ensembl:ENSG00000140749 MIM:606222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DORA
Expression
Biased expression in spleen (RPKM 32.0), appendix (RPKM 25.4) and 13 other tissues See more
Orthologs

Genomic context

See IGSF6 in Genome Data Viewer
Location:
16p12.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (21639550..21652608, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (21652605..21663987, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 5A pseudogene Neighboring gene uncharacterized LOC101927814 Neighboring gene methyltransferase like 9 Neighboring gene RNA, U6 small nuclear 1005, pseudogene Neighboring gene RNA, U6 small nuclear 196, pseudogene Neighboring gene otoancorin Neighboring gene uncharacterized LOC105371126 Neighboring gene RRN3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of immunoglobulin superfamily, member 6 (IGSF6) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
immunoglobulin superfamily member 6
Names
down-regulated by activation (immunoglobulin superfamily)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005849.4NP_005840.2  immunoglobulin superfamily member 6 precursor

    See identical proteins and their annotated locations for NP_005840.2

    Status: VALIDATED

    Source sequence(s)
    AC092719, AJ223183, BC017844, CD369238
    Consensus CDS
    CCDS10599.1
    UniProtKB/Swiss-Prot
    O95976
    Related
    ENSP00000268389.4, ENST00000268389.6
    Conserved Domains (1) summary
    cl11960
    Location:33142
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    21639550..21652608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p13 PATCHES

    Range
    1452220..1465278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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