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INSR insulin receptor [ Camelus ferus (Wild Bactrian camel) ]

Gene ID: 102522017, updated on 11-Apr-2024

Summary

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Gene symbol
INSR
Gene description
insulin receptor
Locus tag
CB1_000320016
See related
EnsemblRapid:ENSCFEG00005019405
Gene type
protein coding
RefSeq status
MODEL
Organism
Camelus ferus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
23
Annotation release Status Assembly Chr Location
102 current BCGSAC_Cfer_1.0 (GCF_009834535.1) 22 NC_045717.1 (22545513..22660003)
101 previous assembly CB1 (GCF_000311805.1) Unplaced Scaffold NW_006210496.1 (350250..509374)

Chromosome 22 - NC_045717.1Genomic Context describing neighboring genes Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene 5S ribosomal RNA Neighboring gene uncharacterized LOC116659108 Neighboring gene methyl-CpG-binding domain protein 3-like 2B Neighboring gene transfer RNA alanine (anticodon AGC)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin receptor
Names
Insulin receptor precursor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Camelus ferus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BCGSAC_Cfer_1.0 Primary Assembly

Genomic

  1. NC_045717.1 Reference BCGSAC_Cfer_1.0 Primary Assembly

    Range
    22545513..22660003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_032466238.1 → XP_032322129.1  insulin receptor isoform X2

    UniProtKB/TrEMBL
    A0A8B8RXS3
    Related
    ENSCFEP00005032679.1, ENSCFET00005036267.1
    Conserved Domains (5) summary
    cd05061
    Location:1015 → 1302
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:867 → 944
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:940 → 986
    Insulin_TMD; Insulin receptor trans-membrane segment

  2. XM_032466237.1 → XP_032322128.1  insulin receptor isoform X1

    UniProtKB/TrEMBL
    A0A8B8RVZ4
    Conserved Domains (5) summary
    cd05061
    Location:1016 → 1303
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:867 → 944
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:940 → 987
    Insulin_TMD; Insulin receptor trans-membrane segment

  3. XM_032466239.1 → XP_032322130.1  insulin receptor isoform X3

    UniProtKB/TrEMBL
    A0A8B8RXG7
    Related
    ENSCFEP00005032733.1, ENSCFET00005036329.1
    Conserved Domains (5) summary
    cd05061
    Location:979 → 1266
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:830 → 907
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:142 → 300
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:322 → 435
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:903 → 950
    Insulin_TMD; Insulin receptor trans-membrane segment
Nucleotide Protein
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