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Gpat4 glycerol-3-phosphate acyltransferase 4 [ Mus musculus (house mouse) ]

Gene ID: 102247, updated on 8-Feb-2024

Summary

Official Symbol
Gpat4provided by MGI
Official Full Name
glycerol-3-phosphate acyltransferase 4provided by MGI
Primary source
MGI:MGI:2142716
See related
Ensembl:ENSMUSG00000031545 AllianceGenome:MGI:2142716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Agpat6; Tsarg7
Summary
Enables glycerol-3-phosphate O-acyltransferase activity. Involved in triglyceride biosynthetic process. Acts upstream of or within several processes, including acylglycerol metabolic process; glandular epithelial cell maturation; and lactation. Located in endoplasmic reticulum. Is expressed in several structures, including adipose tissue; brain; genitourinary system; liver; and mammary gland. Orthologous to human GPAT4 (glycerol-3-phosphate acyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 56.2), CNS E11.5 (RPKM 13.2) and 24 other tissues See more
Orthologs
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Genomic context

See Gpat4 in Genome Data Viewer
Location:
8 A2; 8 11.42 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23661281..23698469, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (23171265..23208453, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene NK6 homeobox 3 Neighboring gene STARR-seq mESC enhancer starr_20914 Neighboring gene predicted gene, 30306 Neighboring gene predicted gene, 30247 Neighboring gene STARR-positive B cell enhancer ABC_E10494 Neighboring gene GINS complex subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E356 Neighboring gene predicted gene, 39141 Neighboring gene golgin A7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycerol-3-phosphate O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycerol-3-phosphate O-acyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glycerol-3-phosphate acyltransferase 6
Names
1-AGP acyltransferase 6
1-AGPAT 6
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
LPAAT-zeta
acyl-CoA:glycerol-3-phosphate acyltransferase 4
lysophosphatidic acid acyltransferase zeta
putative lysophosphatidic acid acyltransferase
testis spermatogenesis apoptosis-related protein 7
NP_061213.2
XP_011240406.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018743.4NP_061213.2  glycerol-3-phosphate acyltransferase 6 precursor

    See identical proteins and their annotated locations for NP_061213.2

    Status: VALIDATED

    Source sequence(s)
    AK083589, AK169257, BY032843, BY271836
    Consensus CDS
    CCDS22189.1
    UniProtKB/Swiss-Prot
    Q3TF78, Q5QHR4, Q8K2C8
    UniProtKB/TrEMBL
    Q3TIF6
    Related
    ENSMUSP00000127325.2, ENSMUST00000167004.3
    Conserved Domains (1) summary
    cd07991
    Location:218427
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    23661281..23698469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242104.4XP_011240406.1  glycerol-3-phosphate acyltransferase 6 isoform X1

    See identical proteins and their annotated locations for XP_011240406.1

    UniProtKB/TrEMBL
    Q3TIF6
    Conserved Domains (1) summary
    cd07991
    Location:218433
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like