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GPAT4 glycerol-3-phosphate acyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 137964, updated on 11-Jun-2021

Summary

Official Symbol
GPAT4provided by HGNC
Official Full Name
glycerol-3-phosphate acyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:20880
See related
Ensembl:ENSG00000158669 MIM:608143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGPAT6; LPAATZ; TSARG7; 1-AGPAT 6; LPAAT-zeta
Summary
Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in endometrium (RPKM 10.2), adrenal (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

See GPAT4 in Genome Data Viewer
Location:
8p11.21
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (41578190..41625001)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41435719..41482520)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 37 Neighboring gene GPAT4 and GINS4 antisense RNA 1 Neighboring gene GINS complex subunit 4 Neighboring gene NK6 homeobox 3 Neighboring gene microRNA 486-1 Neighboring gene microRNA 486-2 Neighboring gene ankyrin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586M1819

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in diacylglycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glandular epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in lactation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glycerol-3-phosphate acyltransferase 4
Names
1-AGP acyltransferase 6
1-acyl-sn-glycerol-3-phosphate acyltransferase zeta
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
glycerol-3-phosphate acyltransferase 6
lysophosphatidic acid acyltransferase zeta
testis spermatogenesis apoptosis-related protein 7
NP_001350126.1
NP_001350127.1
NP_848934.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363197.2NP_001350126.1  glycerol-3-phosphate acyltransferase 4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC009630, AF406612, BU149203, BU620295, DB479618
    Consensus CDS
    CCDS6117.1
    Conserved Domains (1) summary
    cd07991
    Location:218427
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
  2. NM_001363198.2NP_001350127.1  glycerol-3-phosphate acyltransferase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009630, AF406612, BU149203, BU620295
  3. NM_178819.4NP_848934.1  glycerol-3-phosphate acyltransferase 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_848934.1

    Status: VALIDATED

    Source sequence(s)
    AC009630, AF406612, BU620295
    Consensus CDS
    CCDS6117.1
    UniProtKB/Swiss-Prot
    Q86UL3
    UniProtKB/TrEMBL
    Q2TU73
    Related
    ENSP00000380184.3, ENST00000396987.7
    Conserved Domains (1) summary
    cd07991
    Location:218427
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    41578190..41625001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001745474.1 RNA Sequence

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